Captopril does not Potentiate Post-Exercise Hypotension: A Randomized Crossover Study

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Carrenho Queiroz, Andreia Cristiane ; Silva Jr Sousa, Julio Cesar ; Silva, Jr., Natan Daniel ; Tobaldini, Eleonora ; Ortega, Katia Coelho ; De Oliveira, Edilamar Menezes ; Brum, Patricia Chakur ; Montano, Nicola ; Mion, Jr., Decio ; Tinucci, Tais ; De Moraes Forjaz, Claudia Lucia

• Document type: Journal article
• Source: INTERNATIONAL JOURNAL OF SPORTS MEDICINE; v. 38, n. 4, p. 270-277, APR 2017.
• Web of Science Citations: 4

Abstract

To evaluate whether captopril (3 x 50 mg/day) potentiates post-resistance exercise hypotension (PREH) in hypertensives (HT), 12 HT men received captopril and placebo for 4 weeks each in a double-blinded, randomized-crossover design. On each therapy, subjects underwent 2 sessions: Control (C - rest) and Resistance Exercise (RE - 7 exercises, 3 sets to moderate fatigue, 50 % of 1 RM-repetition maximum). Measurements were taken before and after 30-60 min (Post1) and 7 h (Post2), and ambulatory blood pressure (BP) was monitored for 24 h. There were no differences in PREH characteristics and mechanisms between the placebo and captopril periods. At Post1, systolic/diastolic BP decreased significantly and similarly after RE with both therapies (Placebo = -13 +/- 2/ -9 +/- 1 mmHg vs. Captopril = -12 +/- 2/ -10 +/- 1 mmHg, P < 0.05). RE reduced cardiac output in some subjects and systemic vascular resistance in others. Heart rate and cardiac sympathetic modulation increased, while stroke volume and baroreflex sensitivity decreased after RE (Placebo: + 13 +/- 2 bpm, + 21 +/- 5 nu, -11 +/- 5 ml, -4 +/- 2 ms/mmHg; Captopril: + 13 +/- 2 bpm, + 35 +/- 4 nu, 17 +/- 5 ml, -3 +/- 1 ms/mmHg, P < 0.05). At Post2, all variables returned to pre-intervention values. Ambulatory BP was similar between the sessions. Thus, captopril did not potentiate the magnitude and duration of PREH in HT men, and it did not influence PREH mechanisms. (AU)

• FAPESP's process: 11/06689-5 - Post-resistance exercise hypotension in hypertensive men: influence of captopril treatment
• Grantee: Cláudia Lúcia de Moraes Forjaz
• Support Opportunities: Regular Research Grants
• FAPESP's process: 09/18219-3 - POST-RESISTANCE EXERCISE HYPOTENSION IN HYPERTENSIVE MEN: INFLUENCE OF CAPTOPRIL TREATMENT.
• Grantee: Andréia Cristiane Carrenho Queiroz
• Support Opportunities: Scholarships in Brazil - Doctorate