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Post-resistance exercise hypotension in hypertensive men: influence of captopril treatment

Grant number: 11/06689-5
Support Opportunities:Regular Research Grants
Duration: August 01, 2011 - July 31, 2013
Field of knowledge:Health Sciences - Physical Education
Principal Investigator:Cláudia Lúcia de Moraes Forjaz
Grantee:Cláudia Lúcia de Moraes Forjaz
Host Institution: Escola de Educação Física e Esporte (EEFE). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated researchers:Decio Mion Junior ; Patricia Chakur Brum ; Taís Tinucci

Abstract

A single session of resistance exercise promotes post-exercise hypotension in normotensives and hypertensives. Although controversial, the hemodynamic and neural mechanisms associated with this behavior had already been investigated in normotensives. Nevertheless, hypertensive patients presented hemodynamic and neural alterations that might modify post-exercise hypotensive mechanisms, which was not investigated yet. Moreover, hypertensive patients frequently use antihypertensive medications that might also affect post-exercise responses. Thus, the aim of the present study will be to evaluate the behavior of clinic and ambulatory blood pressure (BP), as well as their hemodynamic and neural mechanisms after a single bout of resistance exercise in hypertensive men, comparing these responses with those obtained in normotensive men, and to verify the effects of angiotensin I-converting enzyme inhibitor, captopril, on the responses previously mentioned. Twelve hypertensive men, aged between 30 and 60 years, will receive in a crossover double-blind design placebo or captopril (3 x 50-75 mg/day) for 4 weeks. At the fourth week of each therapy, they will participate in 2 experimental sessions, performed in a random order: Control and Exercise. Moreover, twelve normotensive men, paired with hypertensive by age and body mass index, will also participate in the 2 experimental sessions performed in a random order: Control and Exercise. In the exercise sessions, subjects will realized in 6 resistance exercises, 3 sets of contractions at 50% of 1RM until moderated fatigue. In each session, BP, heart rate, cardiac output, forearm and leg blood flows, vascular reactivity, cardiac and vasomotor autonomic modulation and baroreflex sensitivity will be measured in laboratory before the intervention, 30-60min after the interventions, and also 7 hours after the interventions. Moreover, subjects will undergo a 24-hour ambulatory BP monitoring after the interventions to verify the duration of the hypotensive effect. Data will be compared by a 3-way ANOVA and, Newman-Keul's post-hoc test will be employed whenever necessary. P<0.05 will be accept as statistically significant. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
QUEIROZ, A. C. C.; SOUSA, J. C. S.; CAVALLI, A. A. P.; SILVA, JR., N. D.; COSTA, L. A. R.; TOBALDINI, E.; MONTANO, N.; SILVA, G. V.; ORTEGA, K.; MION, JR., D.; et al. Post-resistance exercise hemodynamic and autonomic responses: Comparison between normotensive and hypertensive men. SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS, v. 25, n. 4, p. 486-494, . (11/06689-5, 09/18219-3)
CARRENHO QUEIROZ, ANDREIA CRISTIANE; SILVA JR SOUSA, JULIO CESAR; SILVA, JR., NATAN DANIEL; TOBALDINI, ELEONORA; ORTEGA, KATIA COELHO; DE OLIVEIRA, EDILAMAR MENEZES; BRUM, PATRICIA CHAKUR; MONTANO, NICOLA; MION, JR., DECIO; TINUCCI, TAIS; et al. Captopril does not Potentiate Post-Exercise Hypotension: A Randomized Crossover Study. INTERNATIONAL JOURNAL OF SPORTS MEDICINE, v. 38, n. 4, p. 270-277, . (11/06689-5, 09/18219-3)

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