A new β-lapachone derivative from Distictella elongata (Vahl) Urb.

Autor(es)

Erdal Bedir ^[1] ; Ana M. S. Pereira ^[2] ; Shabana I. Khan ; Amar Chittiboyina ^[4] ; Rita M. Moraes ; Ikhlas A. Khan ^[6]

Afiliação do(s) autor(es)

^[1] Ege University. Faculty of Engineering. Department of Bioengineering - Turquia

^[2] Universidade de Ribeirão Preto. Departamento de Biotecnologia - Brasil

^[4] University of Mississippi. School of Pharmacy. Department of Medicinal Chemistry

^[6] University of Mississippi. School of Pharmacy. Department of Pharmacognosy

• Tipo de documento: Artigo Científico
• Fonte: Journal of the Brazilian Chemical Society; v. 20, n. 2, p. 383-386, 2009-00-00.

Resumo

The present study describes the structure elucidation of the new β-lapachone type naphthoquinone isolated from the roots of Distictella elongata. Its structure, according to the molecular formula C16H16O6, was identified as 4,7-dihydroxy-10-methoxy-2,2-dimethyl-3,4-dihydro-2H-benzo[h]chromene-5,6-dione. The structure was assigned by spectrometric methods [HRESIMS, 1D NMR (¹H and 13C), and 2D NMR (g-DQF-COSY, g-HMQC and g-HMBC]. Root chloroform extract of D. elongata showed significant inhibition of the growth of SK-MEL (melanoma) and SK-OV-3 (ovary adenocarcinoma) cells with IC50 values of 40 µg mL-1 and 56 µg mL-1, respectively. However, the naphthoquinone was not responsible for the cytotoxic activity exhibited by the extract. (AU)

• Processo FAPESP: 99/10610-1 - Monitoramento e ampliação do banco de germoplasma de plantas medicinais do Cerrado
• Beneficiário: Ana Maria Soares Pereira
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Temático