| Texto completo | |
| Autor(es): |
Erdal Bedir
[1]
;
Ana M. S. Pereira
[2]
;
Shabana I. Khan
;
Amar Chittiboyina
[4]
;
Rita M. Moraes
;
Ikhlas A. Khan
[6]
Número total de Autores: 6
|
| Afiliação do(s) autor(es): | [1] Ege University. Faculty of Engineering. Department of Bioengineering - Turquia
[2] Universidade de Ribeirão Preto. Departamento de Biotecnologia - Brasil
[4] University of Mississippi. School of Pharmacy. Department of Medicinal Chemistry
[6] University of Mississippi. School of Pharmacy. Department of Pharmacognosy
Número total de Afiliações: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Journal of the Brazilian Chemical Society; v. 20, n. 2, p. 383-386, 2009-00-00. |
| Resumo | |
The present study describes the structure elucidation of the new β-lapachone type naphthoquinone isolated from the roots of Distictella elongata. Its structure, according to the molecular formula C16H16O6, was identified as 4,7-dihydroxy-10-methoxy-2,2-dimethyl-3,4-dihydro-2H-benzo[h]chromene-5,6-dione. The structure was assigned by spectrometric methods [HRESIMS, 1D NMR (¹H and 13C), and 2D NMR (g-DQF-COSY, g-HMQC and g-HMBC]. Root chloroform extract of D. elongata showed significant inhibition of the growth of SK-MEL (melanoma) and SK-OV-3 (ovary adenocarcinoma) cells with IC50 values of 40 µg mL-1 and 56 µg mL-1, respectively. However, the naphthoquinone was not responsible for the cytotoxic activity exhibited by the extract. (AU) | |
| Processo FAPESP: | 99/10610-1 - Monitoramento e ampliação do banco de germoplasma de plantas medicinais do Cerrado |
| Beneficiário: | Ana Maria Soares Pereira |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa BIOTA - Temático |