Evaluation of the Osteoinductive Effect of PDGF-BB Associated With Different Carriers in Bone Regeneration in Bone Surgical Defects in Rats

Autor(es)

Silva de Oliveira, Julio Cesar ; Okamoto, Roberta ; Sonoda, Celso Koogi ; Poi, Wilson Roberto ; Garcia Junior, Idelmo Rangel ; Luvizuto, Eloa Rodrigues

• Tipo de documento: Artigo Científico
• Fonte: IMPLANT DENTISTRY; v. 26, n. 4, p. 559-566, AUG 2017.
• Citações Web of Science: 2

Resumo

Purpose: Extensive bone defects in maxillofacial region can be corrected with autograft. However the disadvantages of this type of therapy lead to the search for new bone substitutes. Thus, we evaluated the biological behavior and osteoinductive platelet-derived growth factor type BB (PDGF-BB) associated with different carriers, by histological analysis and immunohistochemical histometric critical defects performed in rat calvaria. Materials and Methods: Critical defects were created with 5-mm diameter calvaria of rats. Each defect was randomly divided into 8 experimental groups, evaluated at 15 and 30 postoperative days for histomorphometry and immunohistochemistry. Results: The results showed new bone formation in all groups, independent of postoperative time. At 30 days, the beta-tricalcium phosphate matrix (TCP) group just did not differ from bone matrix mineralized bovine (BIO) group in the new bone formation (P = 0.1403). In none of the groups' analyzed biomaterials, growth factor stimulated increase in bone formation (P > 0.05). Conclusion: With the methodology used, the growth factor associated with the tested biomaterials did not induce new bone formation. (AU)

• Processo FAPESP: 12/15181-8 - Avaliação do efeito osteoindutivo do PDGF-BB associado a diferentes carreadores na regeneração óssea em cavidades cirurgicamente criadas
• Beneficiário: Eloá Rodrigues Luvizuto
• Modalidade de apoio: Auxílio à Pesquisa - Regular