Composite membranes of alginate and chitosan reinforced with cotton or linen fibers incorporating epidermal growth factor

Autor(es)

Bierhalz, Andrea C. K. ; Moraes, Angela Maria

• Tipo de documento: Artigo Científico
• Fonte: Materials Science & Engineering C-Materials for Biological Applications; v. 76, p. 287-294, JUL 1 2017.
• Citações Web of Science: 7

Resumo

Suture threads of cotton or linen, in crossed and random orientation, were added to alginate-chitosan membranes intended to wound coatings application to improve the mechanical properties. The elongation at break increased to about 5 and 8 times for membranes with linen and cotton, respectively, both in the crossed orientation. The addition of the threads increased roughness and opacity of the membranes and reduced the liquid absorption capacity and water vapor transmission rate. The lowest toxicity to human fibroblasts was observed for extracts of membranes produced with linen, and incorporation in them of epidermal growth factor was able to slightly increase cell proliferation. (C) 2017 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 13/23653-0 - Desenvolvimento de membranas de alginato e quitosana reforçadas com fibras e contendo fator de crescimento para aplicação na engenharia de tecidos
• Beneficiário: Andrea Cristiane Krause Bierhalz
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado