Composite membranes of alginate and chitosan reinforced with cotton or linen fibers incorporating epidermal growth factor

Author(s)

Bierhalz, Andrea C. K. ; Moraes, Angela Maria

• Document type: Journal article
• Source: Materials Science & Engineering C-Materials for Biological Applications; v. 76, p. 287-294, JUL 1 2017.
• Web of Science Citations: 7

Abstract

Suture threads of cotton or linen, in crossed and random orientation, were added to alginate-chitosan membranes intended to wound coatings application to improve the mechanical properties. The elongation at break increased to about 5 and 8 times for membranes with linen and cotton, respectively, both in the crossed orientation. The addition of the threads increased roughness and opacity of the membranes and reduced the liquid absorption capacity and water vapor transmission rate. The lowest toxicity to human fibroblasts was observed for extracts of membranes produced with linen, and incorporation in them of epidermal growth factor was able to slightly increase cell proliferation. (C) 2017 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 13/23653-0 - DEVELOPMENT OF ALGINATE AND CHITOSAN MEMBRANES REINFORCED WITH FIBERS AND CONTAINING GROWTH FACTOR FOR TISSUE ENGINEERING APPLICATIONS
• Grantee: Andrea Cristiane Krause Bierhalz
• Support Opportunities: Scholarships in Brazil - Post-Doctoral