Role of microRNAs on the Regulation of Mitochondrial Biogenesis and Insulin Signaling in Skeletal Muscle

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Lima, Tanes I. ; Araujo, Hygor N. ; Menezes, Eveline S. ; Sponton, Carlos H. ; Araujo, Michel B. ; Bomfim, Lucas H. M. ; Queiroz, Andre L. ; Passos, Madla A. ; Amaral E Sousa, Thais ; Hirabara, Sandro M. ; Martins, Amanda R. ; Sampaio, Helena C. L. B. ; Rodrigues, Alice ; Curi, Rui ; Carneiro, Everardo M. ; Boschero, Antonio C. ; Silveira, Leonardo R.

• Tipo de documento: Artigo de Revisão
• Fonte: Journal of Cellular Physiology; v. 232, n. 5, p. 958-966, MAY 2017.
• Citações Web of Science: 15

Resumo

Mitochondria play a critical role in several cellular processes and cellular homeostasis. Mitochondrion dysfunction has been correlated with numerous metabolic diseases such as obesity and type 2 diabetes. MicroRNAs are non-coding RNAs that have emerged as key regulators of cell metabolism. The microRNAs act as central regulators of metabolic gene networks by leading to the degradation of their target messenger RNA or repression of protein translation. In addition, vesicular and non-vesicular circulating miRNAs exhibit a potential role as mediators of the cross-talk between the skeletal muscle and other tissues/organs. In this review, we will focus on the emerging knowledge of miRNAs controlling mitochondrial function and insulin signaling in skeletal muscle cells. (C) 2016 Wiley Periodicals, Inc. (AU)

• Processo FAPESP: 13/22733-0 - Controle da função mitocondrial por micro-RNAs em células musculares resistentes a insulina: efeito da superexpressão e inibição do miR-696 e miR-let7b
• Beneficiário: Leonardo dos Reis Silveira
• Modalidade de apoio: Auxílio à Pesquisa - Regular