Genetic variants in gastric cancer: Risks and clinical implications

Autor(es)

Gigek, Carolina Oliveira ; Calcagno, Danielle Queiroz ; Rasmussen, Lucas Trevizani ; Santos, Leonardo Caires ; Leal, Mariana Ferreira ; Wisnieski, Fernanda ; Burbano, Rommel Rodriguez ; Lourenco, Laercio Gomes ; Lopes-Filho, Gaspar Jesus ; Cardoso Smith, Marilia Arruda

• Tipo de documento: Artigo de Revisão
• Fonte: Experimental and Molecular Pathology; v. 103, n. 1, p. 101-111, AUG 2017.
• Citações Web of Science: 14

Resumo

Cancer is a multifactorial disease that involves many molecular alterations. Gastric cancer (GC) is the third leading cause of cancer death worldwide. GC is a highly heterogeneous disease with different molecular and genetics features. Therefore, this review focuses on an overview of the genetic aspects of gastric cancer by highlighting the important impact and role of deletions and/or duplications of chromosomal segments, genomic variants, H. pylori infection and interleukin variants, as found in gene expression and newly proposed molecular classification studies. The challenge is to better understand the mechanisms and different pathways that lead to the development and progression of GC. (AU)

• Processo FAPESP: 12/14768-5 - Afecções ortopédicas não traumáticas de ombro: aspectos genéticos e moleculares
• Beneficiário: Mariana Ferreira Leal
• Modalidade de apoio: Bolsas no Brasil - Jovens Pesquisadores
• Processo FAPESP: 11/22548-2 - Afecções ortopédicas não traumáticas de ombro: aspectos genéticos e moleculares
• Beneficiário: Mariana Ferreira Leal
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 16/19953-6 - Genes modulados epigeneticamente poderão constituir alvos terapêuticos em pacientes com câncer gástrico?
• Beneficiário: Fernanda Wisnieski
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado