| Texto completo | |
| Autor(es): |
Pereira, Juliano Alves
;
Mauricio, Adriana Fogagnolo
;
Marques, Maria Julia
;
Neto, Humberto Santo
Número total de Autores: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS; v. 22, n. 5, p. 458-466, SEP 2017. |
| Citações Web of Science: | 2 |
| Resumo | |
Cardiomyopathy related to the absence of dystrophin is an important feature in Duchenne muscular dystrophy (DMD) and in the mdx mouse. Doxycycline (DOX) could be a potential therapy for mdx skeletal muscles dystrophy. We investigated whether the corticoid deflazacort (DFZ) plus DOX could improve cardiac mdx dystrophy better than DFZ alone, later (17 months) in dystrophy. Mdx mice (8 months old) received DFZ/DOX or DFZ for 9 months. The combined therapy was greater than DFZ in reducing fibrosis (60% decrease with DFZ/DOX and 40% with DFZ alone) in the right ventricle and transforming growth factor levels (6.8 +/- 3.2 in untreated mdx mice, 2.8 +/- 1.4 in combined therapy, and 4.6 +/- 1.7 in DFZ; P < .05). Combined therapy more effectively ameliorated cardiac dysfunction (electrocardiogram {[}ECG]) than DFZ. Improvements were seen in the cardiomyopathy index (0.8 +/- 0.1 in combined therapy and 1.0 +/- 0.2 in DFZ), heart rate (418 +/- 46 bpm in combined therapy and 457 +/- 29 bpm in DFZ), QRS interval (11.3 +/- 2 in combined therapy and 13.6 +/- 1 in DFZ), and Q wave amplitude (-40.7 +/- 21 in combined therapy and -90.9 +/- 36 in DFZ). Both therapies decreased markers of inflammation (tumor necrosis factor , nuclear factor B, and metalloproteinase 9). DFZ/DOX improved mdx cardiomyopathy at this stage of the disease, supporting further clinical investigations. (AU) | |
| Processo FAPESP: | 11/51697-6 - Mecanismos de acao do acido eicosapentanoico (epa) na protecao a mionecrose em fibras musculares distroficas |
| Beneficiário: | Maria Julia Marques |
| Linha de fomento: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 08/58491-1 - Mecanismos de proteção da distrofia muscular: estudo proteômico e terapia farmacológica |
| Beneficiário: | Maria Julia Marques |
| Linha de fomento: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 04/15526-9 - Proteínas reguladoras do cálcio e proteção à mionecrose na distrofia muscular de Duchenne |
| Beneficiário: | Maria Julia Marques |
| Linha de fomento: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 12/13577-1 - Biomarcadores da cardiomiopatia para distrofia muscular: estudo metabolômico e terapia farmacológica |
| Beneficiário: | Adriana Fogagnolo Mauricio |
| Linha de fomento: | Bolsas no Brasil - Doutorado |