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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Association between Diastolic Dysfunction with Inflammation and Oxidative Stress in Females ob/ob Mice

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Autor(es):
Sartori, Michelle ; Conti, Filipe F. ; Dias, Danielle da Silva ; dos Santos, Fernando ; Machi, Jacqueline F. ; Palomino, Zaira ; Casarini, Dulce E. ; Rodrigues, Bruno ; de Angelis, Kytia ; Irigoyen, Maria-Claudia
Número total de Autores: 10
Tipo de documento: Artigo Científico
Fonte: FRONTIERS IN PHYSIOLOGY; v. 8, AUG 23 2017.
Citações Web of Science: 5
Resumo

Objective: To evaluate autonomic and cardiovascular function, as well as inflammatory and oxidative stress markers in ob/ob female mice. Methods: Metabolic parameters, cardiac function, arterial pressure (AP), autonomic, hormonal, inflammatory, and oxidative stressmarkers were evaluated in 12-weeks female wild-type (WT group) and ob/ob mice (OB group). Results: OB animals showed increased body weight, blood glucose, and triglyceride levels, along with glucose intolerance, when compared to WT animals. Ejection fraction (EF) and AP were similar between groups; however, the OB group presented diastolic dysfunction, as well as an impairment on myocardial performance index. Moreover, the OB group exhibited important autonomic dysfunction and baroreflex sensitivity impairment, when compared to WT group. OB group showed increased Angiotensin II levels in heart and renal tissues; decreased adiponectin and increased inflammatory markers in adipose tissue and spleen. Additionally, OB mice presented a higher damage to proteins and lipoperoxidation and lower activity of antioxidant enzymes in kidney and heart. Correlations were found between autonomic dysfunction with angiotensin II and inflammatory mediators, as well as between inflammation and oxidative stress. Conclusions: Our results showed that female adult ob/ob mice presented discrete diastolic dysfunction accompanied by autonomic disorder, which is associated with inflammation and oxidative stress in these animals. (AU)

Processo FAPESP: 10/17188-4 - Mecanismos associados às disfunções em um modelo experimental de menopausa e síndrome metabólica: papel do treinamento físico aeróbio ou resistido
Beneficiário:Janaina de Oliveira Brito
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 15/11223-6 - Curso temporal das alterações neuroimunes induzidas pelo consumo crônico de frutose em ratos normotensos e hipertensos: papel do treinamento físico aeróbio
Beneficiário:Kátia de Angelis Lobo D Avila
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 11/15828-9 - Efeitos do treinamento físico combinado em modelo experimental de disfunções cardiometabólicas associadas à privação dos hormônios ovarianos.
Beneficiário:Filipe Fernandes Conti
Linha de fomento: Bolsas no Brasil - Mestrado