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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Association between Diastolic Dysfunction with Inflammation and Oxidative Stress in Females ob/ob Mice

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Author(s):
Sartori, Michelle ; Conti, Filipe F. ; Dias, Danielle da Silva ; dos Santos, Fernando ; Machi, Jacqueline F. ; Palomino, Zaira ; Casarini, Dulce E. ; Rodrigues, Bruno ; de Angelis, Kytia ; Irigoyen, Maria-Claudia
Total Authors: 10
Document type: Journal article
Source: FRONTIERS IN PHYSIOLOGY; v. 8, AUG 23 2017.
Web of Science Citations: 5
Abstract

Objective: To evaluate autonomic and cardiovascular function, as well as inflammatory and oxidative stress markers in ob/ob female mice. Methods: Metabolic parameters, cardiac function, arterial pressure (AP), autonomic, hormonal, inflammatory, and oxidative stressmarkers were evaluated in 12-weeks female wild-type (WT group) and ob/ob mice (OB group). Results: OB animals showed increased body weight, blood glucose, and triglyceride levels, along with glucose intolerance, when compared to WT animals. Ejection fraction (EF) and AP were similar between groups; however, the OB group presented diastolic dysfunction, as well as an impairment on myocardial performance index. Moreover, the OB group exhibited important autonomic dysfunction and baroreflex sensitivity impairment, when compared to WT group. OB group showed increased Angiotensin II levels in heart and renal tissues; decreased adiponectin and increased inflammatory markers in adipose tissue and spleen. Additionally, OB mice presented a higher damage to proteins and lipoperoxidation and lower activity of antioxidant enzymes in kidney and heart. Correlations were found between autonomic dysfunction with angiotensin II and inflammatory mediators, as well as between inflammation and oxidative stress. Conclusions: Our results showed that female adult ob/ob mice presented discrete diastolic dysfunction accompanied by autonomic disorder, which is associated with inflammation and oxidative stress in these animals. (AU)

FAPESP's process: 15/11223-6 - Time course of neuroimmune changes induced by chronic fructose consumption in normotensive and hypertensive rats: role of aerobic exercise training
Grantee:Kátia de Angelis Lobo D Avila
Support type: Regular Research Grants
FAPESP's process: 11/15828-9 - Effects of combined exercise training in an experimental model of cardiometabolic disorders associated with ovarian hormone deprivation.
Grantee:Filipe Fernandes Conti
Support type: Scholarships in Brazil - Master
FAPESP's process: 10/17188-4 - Dysfunction associated mechanisms to a menopause and syndrome metabolic experimental model: role of aerobic and resistance exercise training
Grantee:Janaina de Oliveira Brito
Support type: Scholarships in Brazil - Doctorate