Effects of combined exercise training in an experimental model of cardiometabolic disorders associated with ovarian hormone deprivation.

• Grant number: 11/15828-9
• Support Opportunities: Scholarships in Brazil - Master
• Start date: March 01, 2012
• End date: December 31, 2013
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Kátia de Angelis Lobo D Avila
• Grantee: Filipe Fernandes Conti
• Host Institution: Universidade Nove de Julho (UNINOVE). Campus Memorial. São Paulo , SP, Brazil

Abstract

The incidence of hypertension, insulin resistance, type 2 diabetes and the morbidity and mortality increased after the menopause event. On the other hand, aerobic exercise training has been recommended as an important therapy for the prevention and treatment of cardio-metabolic disorders, according to the recognized benefits of this approach in different populations. Recently, resistance exercise training has been recommended in addition to aerobic training (combined training) in the treatment of cardiovascular and metabolic diseases, however, little is known about the physiological benefits of this approach. In addition, the mechanisms involved in the possible benefits of combined dynamic exercise training were not well studied after ovarian hormone deprivation, especially in the presence of cardio-metabolic disorders. Thus, the purpose of this study is to investigate the effects of combined dynamic exercise training in hypertensive ovariectomized rats submitted to fructose overload. The rats will be divided into 6 groups: control Wistar rats (SC); and spontaneously hypertensive rats (SHR) submitted (SHO) or not (SH) to the ovarian hormone deprivation, SHR ovariectomized chronic treated with fructose sedentary (SHOF) or trained (CHOF). The combined exercise training will be conducted on a treadmill and stair adapted to rats, on alternate days. Parameters of cardiovascular function (blood pressure, BP, and heart rate, HR), cardiovascular autonomic modulation (heart rate and blood pressure variability and baroreflex sensitivity), metabolic (body weight, adipose tissue, blood glucose and triglycerides, insulin tolerance) and exercise capacity (maximal running test on treadmill and maximal load test on stair), and their relationship with parameters of oxidative stress (lipid peroxidation by chemiluminescence; redox balance by oxidized glutathione/reduced gluthatione ratio; carbonylated proteins; production of superoxide anion and hydrogen peroxide; catalase, glutathione peroxidase and superoxide dismutase activities; and total antioxidant capacity), nitric oxide metabolism (plasmatic nitrite and nitrate concentrations) and inflammation (leptin, adiponectin, TNF alpha, IL-6 and IL -10) will be evaluated. The results of this study will contribute to a better understanding of the mechanisms involved in the association of risk factors in women as well as to verify the effects of combined exercise training in a model that associated ovarian hormone deprivation and cardio-metabolic disorders.

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CONTI, FILIPE FERNANDES; BRITO, JANAINA DE OLIVEIRA; BERNARDES, NATHALIA; DIAS, DANIELLE DA SILVA; SANCHES, IRIS CALLADO; MALFITANO, CHRISTIANE; FRANCISCA LLESUY, SUSANA; IRIGOYEN, MARIA-CLAUDIA; DE ANGELIS, KATIA. Cardiovascular autonomic dysfunction and oxidative stress induced by fructose overload in an experimental model of hypertension and menopause. BMC CARDIOVASCULAR DISORDERS, v. 14, DEC 11 2014. (12/20141-5, 10/17188-4, 11/15828-9)

SARTORI, MICHELLE; CONTI, FILIPE F.; DIAS, DANIELLE DA SILVA; DOS SANTOS, FERNANDO; MACHI, JACQUELINE F.; PALOMINO, ZAIRA; CASARINI, DULCE E.; RODRIGUES, BRUNO; DE ANGELIS, KYTIA; IRIGOYEN, MARIA-CLAUDIA. Association between Diastolic Dysfunction with Inflammation and Oxidative Stress in Females ob/ob Mice. FRONTIERS IN PHYSIOLOGY, v. 8, AUG 23 2017. (10/17188-4, 15/11223-6, 11/15828-9)

CONTI, FILIPE FERNANDES; BRITO, JANAINA DE OLIVEIRA; BERNARDES, NATHALIA; DIAS, DANIELLE DA SILVA; MALFITANO, CHRISTIANE; MORRIS, MARIANA; FRANCISCA LLESUY, SUSANA; IRIGOYEN, MARIA-CLAUDIA; DE ANGELIS, KATIA. Positive effect of combined exercise training in a model of metabolic syndrome and menopause: autonomic, inflammatory, and oxidative stress evaluations. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, v. 309, n. 12, p. R1532-R1539, DEC 15 2015. (12/20141-5, 11/15828-9)

CONTI, FILIPE FERNANDES; IRIGOYEN, MARIA-CLAUDIA; SARTORI, MICHELLE; RIBEIRO, AMANDA APARECIDA; DOS SANTOS, FERNANDO; MACHI, JACQUELINE FREIRE; TABOAS FIGUEROA, DIEGO MENDROT; RODRIGUES, BRUNO; DE ANGELIS, KATIA. Aerobic Training Is Better Than Resistance Training on Cardiac Function and Autonomic Modulation in Female ob/ob Mice. FRONTIERS IN PHYSIOLOGY, v. 10, DEC 5 2019. (18/17183-4, 10/17188-4, 18/19006-2, 15/11223-6, 11/15828-9)

CONTI, FILIPE F.; BRITO, JANAINA O.; DIAS, DANIELLE S.; BERNARDES, NATHALIA; MALFITANO, CHRISTIANE; IRIGOYEN, MARIA-CLAUDIA; DE ANGELIS, KATIA. Combined Exercise Training Promotes Additional Benefits Than Aerobic or Resistance Training in a Model of Metabolic Syndrome and Menopause. FASEB JOURNAL, v. 30, p. 2-pg., 2016-04-01. (10/17188-4, 12/20141-5, 11/15828-9)