Aerobic Training Is Better Than Resistance Training on Cardiac Function and Autonomic Modulation in Female ob/ob Mice

Author(s)

Conti, Filipe Fernandes ^{[1, 2]} ; Irigoyen, Maria-Claudia ^[3] ; Sartori, Michelle ^[3] ; Ribeiro, Amanda Aparecida ^[3] ; dos Santos, Fernando ^[3] ; Machi, Jacqueline Freire ^{[4, 3]} ; Taboas Figueroa, Diego Mendrot ^[3] ; Rodrigues, Bruno ^[5] ; De Angelis, Katia ^{[6, 1]}

Affiliation

^[1] Univ Nove de Julio UNINOVE, Translat Physiol Lab, Sao Paulo, SP - Brazil

^[2] Nova Southeastern Univ, Coll Pharm, Hlth Profess Div, Ft Lauderdale, FL 33314 - USA

^[3] Univ Sao Paulo, Med Sch, Heart Inst InCor, Hypertens Unit, Sao Paulo, SP - Brazil

^[4] Univ Miami, Dept Mol & Cellular Pharmacol, Coral Gables, FL 33124 - USA

^[5] Univ Estadual Campinas, Dept Adapted Phys Act, Fac Phys Educ, Campinas, SP - Brazil

^[6] Fed Univ Sao Paulo UNIFESP, Dept Physiol, Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: FRONTIERS IN PHYSIOLOGY; v. 10, DEC 5 2019.
• Web of Science Citations: 0

Abstract

Objective: This study evaluated the effects of aerobic, resistance, and combined exercise training on cardiac function and autonomic modulation in female ob/ob mice. Methods: Four-week-old female wild type and obese (ob/ob) mice were divided into five groups (n = 8): control (WT), obese (OB) obese + aerobic training (OBA), obese + resistance training (OBR), and obese + combined training (OBC). The exercise training was performed on treadmill and/or ladder at 40-60% maximum test during 8 weeks. Cardiac function was measured using echo machine. Heart rate variability (HRV) was evaluated in the time and frequency domain. Results: OB group presented higher body weight gain (similar to 600%), glycemia (similar to 44%) and glucose intolerance (similar to 150%), reduction of cardiac vagal modulation, evidenced by a lower RMMSD (similar to 56%), total power and high frequency band, and a higher isovolumic relaxation time (IVRT) (similar to 24%) in relation to the WT group. Aerobic and combined training led to a lower IVRT (OBA: similar to 14%; OBC: similar to 14%) and myocardial global index (OBA: similar to 37%; OBC: similar to 44%). The OBA group presented an increased in vagal indexes of HRV than the other ob/ob groups. A negative correlation was observed between the delta of aerobic exercise capacity and MPI (r = 0.45; p = 0.002) and exercise capacity and body weight gain (r = 0.39; p = 0.002). Conclusion: Only the obese females underwent to aerobic exercise training showed improvement in cardiac function and HRV. Moreover, the aerobic exercise capacity as well as a greater responsivity to aerobic exercise training is intimately associated with these improvements, reinforcing the importance of aerobic exercise training to this population. (AU)

• FAPESP's process: 18/17183-4 - Fructose overload in genitors: impact of exercise training on cardiometabolic and neuroimmune changes in offspring
• Grantee: Kátia de Angelis Lobo D Avila
• Support type: Regular Research Grants
• FAPESP's process: 10/17188-4 - Dysfunction associated mechanisms to a menopause and syndrome metabolic experimental model: role of aerobic and resistance exercise training
• Grantee: Janaina de Oliveira Brito
• Support type: Scholarships in Brazil - Doctorate
• FAPESP's process: 18/19006-2 - ASSOCIATION BETWEEN SERUM AND FUNCTIONAL BIOMARKERS, AND IMAGE EXAMS IN DIASTOLIC AND COGNITIVE DYSFUNCTIONS
• Grantee: Maria Claudia Costa Irigoyen
• Support type: Regular Research Grants
• FAPESP's process: 15/11223-6 - Time course of neuroimmune changes induced by chronic fructose consumption in normotensive and hypertensive rats: role of aerobic exercise training
• Grantee: Kátia de Angelis Lobo D Avila
• Support type: Regular Research Grants
• FAPESP's process: 11/15828-9 - Effects of combined exercise training in an experimental model of cardiometabolic disorders associated with ovarian hormone deprivation.
• Grantee: Filipe Fernandes Conti
• Support type: Scholarships in Brazil - Master