| Grant number: | 18/19006-2 |
| Support type: | Regular Research Grants |
| Duration: | March 01, 2019 - May 31, 2021 |
| Field of knowledge: | Health Sciences - Medicine |
| Principal researcher: | Maria Claudia Costa Irigoyen |
| Grantee: | Maria Claudia Costa Irigoyen |
| Home Institution: | Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil |
| Assoc. researchers: | Fernanda Marciano Consolim-Colombo |
Abstract
Diastolic dysfunction (DD) and cognitive dysfunction (DC) are asymptomatic alterações that precede severe conditions, as heart failure and dementia. Several risk factors contribute to DD and DC development, for instance, hypertension and aging. In order to prevent and treat these dysfunctions, and avoid worse outcomes, it is necessary to shed light on the knowledge about DD and DC pathophysiological process, and how they interact with each other. Additionally, fast, early and effective diagnostic methods for DD and Dc are lacking. In this context, our proposal is, in the first attempt, to evaluate echocardiographic and brain magnetic resonance in two models: a) an animal model (mice under transverse aortic coarctation), b) a human model (hypertensive patients), as both present DD and DC. Before the observed alterations, we will apply metabolomics to identify serum markers which are common to both dysfunctions, and we will correlate them with functional and image alterations. Therefore, we intend to validate these biomarkers as a method of early DD diagnostic. As the mechanisms of progression from the DD asymptomatic state to heart failure are not well known, and DD is strongly related to DC, success in this project will help not only in translational knowledge generation and diffusion, but will also disseminate the importance of giving attention to these early alterations (AU)