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ASSOCIATION BETWEEN SERUM AND FUNCTIONAL BIOMARKERS, AND IMAGE EXAMS IN DIASTOLIC AND COGNITIVE DYSFUNCTIONS

Abstract

Diastolic dysfunction (DD) and cognitive dysfunction (DC) are asymptomatic alterações that precede severe conditions, as heart failure and dementia. Several risk factors contribute to DD and DC development, for instance, hypertension and aging. In order to prevent and treat these dysfunctions, and avoid worse outcomes, it is necessary to shed light on the knowledge about DD and DC pathophysiological process, and how they interact with each other. Additionally, fast, early and effective diagnostic methods for DD and Dc are lacking. In this context, our proposal is, in the first attempt, to evaluate echocardiographic and brain magnetic resonance in two models: a) an animal model (mice under transverse aortic coarctation), b) a human model (hypertensive patients), as both present DD and DC. Before the observed alterations, we will apply metabolomics to identify serum markers which are common to both dysfunctions, and we will correlate them with functional and image alterations. Therefore, we intend to validate these biomarkers as a method of early DD diagnostic. As the mechanisms of progression from the DD asymptomatic state to heart failure are not well known, and DD is strongly related to DC, success in this project will help not only in translational knowledge generation and diffusion, but will also disseminate the importance of giving attention to these early alterations (AU)

Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DIAS MOREIRA, NATHALIA JUOCYS; DOS SANTOS, FERNANDO; MOREIRA, EDSON DIAS; FARAH, DANIELA; DE SOUZA, LEANDRO EZIQUIEL; DA SILVA, MAIKON BARBOSA; MORAES-SILVA, IVANA CINTHYA; LINCEVICIUS, GISELE SILVERIO; CALDINI, ELIA GARCIA; COSTA IRIGOYEN, MARIA CLAUDIA. Acute renal denervation normalizes aortic function and decreases blood pressure in spontaneously hypertensive rats. SCIENTIFIC REPORTS, v. 10, n. 1 DEC 11 2020. Web of Science Citations: 0.
S.C.F. FREITAS; C. PAIXÃO DOS SANTOS; A. ARNOLD; F.F. STOYELL-CONTI; M.R.H. DUTRA; M. VERAS; M.C. IRIGOYEN; K. DE ANGELIS. A method to assess heart rate variability in neonate rats: validation in normotensive and hypertensive animals. Brazilian Journal of Medical and Biological Research, v. 53, n. 8, p. -, 2020. Web of Science Citations: 0.
CONTI, FILIPE FERNANDES; IRIGOYEN, MARIA-CLAUDIA; SARTORI, MICHELLE; RIBEIRO, AMANDA APARECIDA; DOS SANTOS, FERNANDO; MACHI, JACQUELINE FREIRE; TABOAS FIGUEROA, DIEGO MENDROT; RODRIGUES, BRUNO; DE ANGELIS, KATIA. Aerobic Training Is Better Than Resistance Training on Cardiac Function and Autonomic Modulation in Female ob/ob Mice. FRONTIERS IN PHYSIOLOGY, v. 10, DEC 5 2019. Web of Science Citations: 0.
DIAS, DANIELLE DA SILVA; MORAES-SILVA, IVANA C.; BERNARDES, NATHALIA; BRITO-MONZANI, JANAINA DE OLIVEIRA; STOYELL-CONTI, FILIPE FERNANDES; MACHI, JACQUELINE FREIRE; LLESUY, SUSANA; IRIGOYEN, MARIA-CLAUDIA; DE ANGELIS, KATIA. Exercise training initiated at old stage of lifespan attenuates aging-and ovariectomy-induced cardiac and renal oxidative stress: Role of baroreflex. Experimental Gerontology, v. 124, SEP 2019. Web of Science Citations: 0.

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