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Mechanisms associated with the development of complications of type 2 diabetes in female mice ob/ ob: preventive role of physical training aerobic dynamic, resistance or combined

Grant number: 11/20859-0
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): March 01, 2012
Effective date (End): February 28, 2015
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal researcher:Maria Claudia Costa Irigoyen
Grantee:Michelle Sartori
Home Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil


The aim of this study is to evaluate the role of aerobic, resistance or combined (aerobic+resistance) exercise training in the development of type 2 diabetes, analyzing the mechanisms associated with diabetes complications in female mice with leptin production deficiency (ob/ob). For this purpose, 48 female mice, initially with 4 weeks of age, will be used and divided into six groups: sedentary wild type (SS), 4-week old ob/ob sedentary (OS-4), 12-week old ob/ob sedentary (OS-12), ob/ob aerobic training (OAT), ob/ob resistance training (ORT) and ob/ob combined training (OCT). The trained groups will undergo eight weeks of dynamic aerobic exercise training on a treadmill (50 to 60% of the maximum speed of the exercise test) or resistance ladder climb (40-60% of maximum load) or the combination of the two training sessions (combined). At the end of the protocol (four weeks for group OS-4 and 12 weeks for the other groups) it will be evaluated: body weight; blood glucose, triglycerides and cholesterol; blood pressure and heart rate; baroreflex sensitivity; cardiovascular autonomic modulation; oxidative stress parameters; and hormonal and inflammatory markers. Our results may contribute to the understanding of the mechanisms responsible for the development of diabetes in women, as well as enable to assess and compare the effects of aerobic, resistance or combined training, demonstrating the importance of physical activity in preventing disorders associated with diabetes.