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Study of correlation of adaptations on cardiac autonomic modulation and metabolic parameters in women with polycystic ovary syndrome submitted to aerobic physical training

Grant number: 08/07561-0
Support Opportunities:Regular Research Grants
Duration: February 01, 2009 - January 31, 2011
Field of knowledge:Health Sciences - Physiotherapy and Occupational Therapy
Principal Investigator:Hugo Celso Dutra de Souza
Grantee:Hugo Celso Dutra de Souza
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Women with polycystic ovary syndrome (PCOS) have high prevalence of obesity. In addition to obesity, this disease is also associated with insulin resistance and hyperinsulinemia, which increases the risk of cardiovascular diseases. Our hypothesis is based on the possibility that this endocrine-metabolic syndrome can promote relevant autonomic changes, thus impairing the cardiac autonomic control regardless of the comorbities associated (e.g. obesity). On the other hand, physical training has been used as adjunctive treatment for several diseases in order to promote beneficial adaptations to the individual, including improvement of the cardiovascular autonomic control. Therefore, our objective is to characterize the impairment of the cardiac autonomic modulation in women with polycystic ovary according to different levels of obesity. Additionally, the effect of aerobic physical training on polycystic ovary syndrome will also be investigated by focusing on body constitution, metabolic adaptations, and cardiac autonomic modulation. Female volunteers aged 18 to 39 years old presenting different percentages of body fat, with or without non-treated polycystic ovary, will be submitted to analysis of cardiac autonomic modulation in association with ergospirometric evaluation, body constitution, and laboratory exams to determining serum triglyceride levels, cholesterol fractions, fasting glycaemia, glucose tolerance, insulin and insulin sensitivity, catecholamine, leptin, adiponectin, and factor TNF-alfa prior to and after the 16-week aerobic-training protocol. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
COZZA, IZABELA C.; DI SACCO, THAISA H. R.; MAZON, JOSE H.; SALGADO, MARIA CRISTINA O.; DUTRA, SABRINA G. V.; CESARINO, EVANDRO J.; SOUZA, HUGO C. D.. Physical exercise improves cardiac autonomic modulation in hypertensive patients independently of angiotensin-converting enzyme inhibitor treatment. HYPERTENSION RESEARCH, v. 35, n. 1, p. 82-87, . (08/07561-0)

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