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Cardiovascular autonomic modulation in experimental model of menopause: comparison between aerobic, resistance and combined exercise training

Grant number: 16/21302-3
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): February 01, 2017
Effective date (End): December 31, 2017
Field of knowledge:Health Sciences - Physical Education
Principal Investigator:Iris Callado Sanches
Grantee:Gabrielly Minguta Santos Costa
Home Institution: Faculdade de Ciências Biológicas e da Saúde. Universidade São Judas Tadeu (USJT). São Paulo , SP, Brazil

Abstract

Considering the association of various risk factors in women after menopause, aggravated by sedentary lifestyle, interventions to prevent or minimize the morbidity and mortality in this population have been widely studied by researchers. Despite the consensus of the importance of the recommendation of regular exercise for cardiovascular health of women, these benefits have been observed mainly due to the aerobic regular physical activity, while results of studies involving other types of exercise, such as resistance and combined (aerobic + resistance) are scarce and controversial. Thus, the aim of this study is to compare the effects of aerobic, resistance and combined (aerobic + resistance, every other day) exercise training on physical capacity (maximum test running on a treadmill and maximum load test staircase), metabolic parameters (body weight, blood glucose and insulin resistance), hemodynamic parameters (blood pressure [BP] and heart rate [HR]) and cardiovascular autonomic modulation (HR and systolic BP variabilities) in an experimental model of menopause. To this, 32 female Wistar rats will be used divided into 4 experimental groups (n = 8 each): sedentary ovariectomized (OS); ovariectomized subjected to aerobic (OTA), resistance (OTR) or combined [aerobic+resistance, on alternate days] (OTC) exercise training protocol. At the end of 8 weeks of follow-up or exercise training, metabolic evaluations will be performed (blood glucose and insulin tolerance), and the animals are cannulated for direct recording of blood pressure (CODAS, 2kHz). Blood pressure records will be evaluated with the spectral analysis tool (FFT) for analysis of cardiovascular autonomic modulation. The data will be statistically analyzed using one-way ANOVA test, and p0.05 values will be considered significant. (AU)