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Impact of combined exercise training on cardiovascular autonomic control and mortality in diabetic ovariectomized rats

Abstract

The purpose of this study was to compare the effects of aerobic, resistance, or combined exercise training on cardiovascular autonomic control and mortality in diabetic ovariectomized rats. Female Wistar rats were divided into euglycemic sedentary (ES), and diabetic ovariectomized sedentary (DOS) or aerobic (DOTA), resistance (DOTR) and aerobic+resistance (DOTC) trained groups. Arterial pressure (AP) was directly recorded and baroreflex sensitivity was evaluated by heart rate responses to AP changes. Cardiovascular autonomic modulation was evaluated by spectral analyses. No differences were observed in body weight and glycemia between diabetics. DOTC and DOTA groups had an increase in running time, while DOTC and DOTR groups showed increased strength. Trained groups presented improvement in total power and high frequency band of pulse interval and reduced mortality (vs. DOS). The DOTC (bradycardic and tachycardic responses) and DOTA (tachycardic responses) groups showed attenuation in baroreflex dysfunction observed in DOS and DOTR, as well as an improvement in AP variance. In conclusion, all training protocols led to reduced mortality, which may be due to an increase in physical capacity and to cardiovascular and autonomic benefits following training, regardless of any improvement in glycemic control. In this model, the aerobic and combined trainings seem to promote additional cardiovascular autonomic benefits when compared to resistance training alone. (AU)