Cardiovascular diseases (CVD) are the leading cause of mortality around the world. Women have a cardiovascular protection when compared to men before menopause; however, with the advent of menopause this cardioprotection is reduced, then followed by sedentary lifestyle and a reduction of force, makes women more susceptible to development of chronic degenerative diseases. The benefits of physical activity are widely studied and reported in the treatment and prevention of cardio-metabolic dysfunctions. In the present study we will analyze the effect of combined exercise training (aerobic + resistance) on hemodynamic, autonomic, oxidative stress and inflammation in an experimental model of ovariectomized spontaneously hypertensive rats (SHR). The training will be conducted on a treadmill and stairs adapted to rat on alternate days. Cardiovascular function parameters (blood pressure, BP, and heart rate, HR), autonomic regulation (HR and BP variability and baroreflex sensitivity) and the physical capacity (maximal test on treadmill and maximum load test on ladder) and their relationship to changes in oxidative stress (lipid peroxidation by chemiluminescence, protein carbonylated, redox balance by the ratio of oxidized and reduced glutathione, superoxide anion production and hydrogen peroxide concentration, catalase, glutathione peroxidase, superoxide dismutase, total antioxidant capacity), metabolization of nitric oxide (nitrite and nitrate concentration in plasma) and inflammation (leptin, adponectina, TNF alpha, IL-6, IL-10) parameters will be evaluated. The results of this study may contribute to a better understanding: 1) the mechanisms involved in the association of risk factors in females; 2) the effects of combined exercise training in a model of hypertension associated with ovarian hormone deprivation.
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