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Effects of aerobic or resistance exercise training on autonomic parameters and oxidative stress in ovariectomized hypertensive rats

Grant number: 11/16441-0
Support type:Scholarships in Brazil - Master
Effective date (Start): March 01, 2012
Effective date (End): December 31, 2012
Field of knowledge:Health Sciences - Physical Education
Principal Investigator:Kátia de Angelis Lobo D Avila
Grantee:Renata Kelly da Palma
Home Institution: Universidade Nove de Julho (UNINOVE). Campus Memorial. São Paulo , SP, Brazil


Cardiovascular diseases (CVD) are the leading cause of mortality nowadays. At menopause, due to deprivation of female sex hormones, increase risks of cardiac events. In this period, the women become more sedentary, which is a major risk factor for hypertension? Well known the role of cardiovascular and autonomic system and how the oxidative stress can damage it, intervention which decreases the oxidative stress and/or improve autonomic function has been seen as strategies in the management of cardiovascular risks. Thus, the benefits of physical exercise are presented as a way to improve of autonomic and cardiovascular dysfunction However, the physiological mechanisms involved in this benefits has not been so much studied in women after menopause, especially the effects of aerobic and resistance in hypertension. Therefore, the aim of this study will be evaluate the effects of aerobic exercise training (8 weeks on a treadmill), resistance exercise training (8 weeks on adapted stairs to rats) in cardiovascular autonomic control (blood pressure [BP] and heart rate [HR] registered directly; baroreflex sensitivity, heart rate and systolic arterial pressure variability), as well as oxidative stress, antioxidant enzyme activities. The rats (10 weeks old) will be divided in five groups (n=8 in each group): control group; hypertensive group; ovariectomy (bilateral removal of ovaries) group, ovariectomy hypertensive sedentary and hypertensive trained aerobic and resistance groups. The results of this project can help to understanding the mechanisms responsible from physiological benefits induced by aerobic and resistance exercise in reduce hypertension in postmenopausal women, as well as the search for approaches more accurate diagnosis and treatment of cardiovascular disease in postmenopausal women, so further studies may show decrease of morbidity and mortality in this population.

Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SHIMOJO, GUILHERME LEMOS; DIAS, DANIELLE DA SILVA; MALFITANO, CHRISTIANE; SANCHES, IRIS CALLADO; LLESUY, SUSANA; ULLOA, LUIS; IRIGOYEN, MARIA-CLAUDIA; DE ANGELIS, KATIA. Combined Aerobic and Resistance Exercise Training Improve Hypertension Associated With Menopause. FRONTIERS IN PHYSIOLOGY, v. 9, OCT 29 2018. Web of Science Citations: 2.
DA PALMA, RENATA K.; MORAES-SILVA, IVANA C.; DIAS, DANIELLE DA SILVA; SHIMOJO, GUILHERME L.; CONTI, FILIPE F.; BERNARDES, NATHALIA; BARBOZA, CATARINA A.; SANCHES, IRIS C.; DA ROSA ARAUJO, ALEX SANDER; IRIGOYEN, MARIA-CLAUDIA; DE ANGELIS, KATIA. Resistance or aerobic training decreases blood pressure and improves cardiovascular autonomic control and oxidative stress in hypertensive menopausal rats. Journal of Applied Physiology, v. 121, n. 4, p. 1032-1038, OCT 1 2016. Web of Science Citations: 10.
SHIMOJO, G. L.; PALMA, R. K.; BRITO, J. O.; SANCHES, I. C.; IRIGOYEN, M. C.; DE ANGELIS, K. Dynamic resistance training decreases sympathetic tone in hypertensive ovariectomized rats. Brazilian Journal of Medical and Biological Research, v. 48, n. 6, p. 523-527, JUN 2015. Web of Science Citations: 10.
FILIPE FERNANDES CONTI; IRIS CALLADO SANCHES; NATHALIA BERNARDES; GUILHERME LEMOS SHIMOJO; DIEGO MENDROT TABOAS FIGUEROA; ROGÉRIO BRANDÃO WICHI; KÁTIA DE ANGELIS. Influência dos hormônios sexuais no consumo de oxigênio de ratos. Revista Brasileira de Medicina do Esporte, v. 20, n. 6, p. -, Dez. 2014.

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