| Full text | |
| Author(s): |
Shimojo, G. L.
[1]
;
Palma, R. K.
[1]
;
Brito, J. O.
[1]
;
Sanches, I. C.
[1]
;
Irigoyen, M. C.
[2]
;
De Angelis, K.
[1]
Total Authors: 6
|
| Affiliation: | [1] Univ Nove Julho, Programa Ciencias Reabilitacao, Lab Fisiol Translacional, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Fac Med, Inst Coracao, Sao Paulo, SP - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | Brazilian Journal of Medical and Biological Research; v. 48, n. 6, p. 523-527, JUN 2015. |
| Web of Science Citations: | 10 |
| Abstract | |
The aim of this study was to investigate the effects of resistance exercise training on hemodynamics and cardiac autonomic control in ovariectomized spontaneously hypertensive rats. Female rats were divided into 4 groups: sedentary control (SC), sedentary hypertensive (SH), sedentary hypertensive ovariectomized (SHO), and resistance-trained hypertensive ovariectomized (RTHO). Resistance exercise training was performed on a vertical ladder (5 days/week, 8 weeks) at 40-60% maximal load. Direct arterial pressure was recorded. Vagal and sympathetic tones were measured by heart rate (HR) responses to methylatropine (3 mg/kg, iv) and propranolol (4 mg/kg, iv). Ovariectomy resulted in additional increases in blood pressure in hypertensive rats and was associated with decreased vagal tone. Resistance exercise trained rats had lower mean arterial pressure than untrained rats (RTHO: 159±2.2 vs SHO: 177±3.4 mmHg), as well as resting bradycardia (RTHO: 332±9.0 vs SHO: 356±5 bpm). Sympathetic tone was also lower in the trained group. Moreover, sympathetic tone was positively correlated with resting HR (r=0.7, P<0.05). The additional arterial pressure increase in hypertensive rats caused by ovarian hormone deprivation was attenuated by moderate-intensity dynamic resistance training. This benefit may be associated with resting bradycardia and reduced cardiac sympathetic tone after training, which suggests potential benefits of resistance exercise for the management of hypertension after ovarian hormone deprivation. (AU) | |
| FAPESP's process: | 12/20141-5 - Effects of aerobic,resistance or combined exercise training in experimental models of cardiometabolic disorders associated with ovarian hormone deprivation |
| Grantee: | Kátia de Angelis Lobo D Avila |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 11/16441-0 - Effects of aerobic or resistance exercise training on autonomic parameters and oxidative stress in ovariectomized hypertensive rats |
| Grantee: | Renata Kelly da Palma |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 12/02023-5 - Effects of resistance exercise training on hemodynamic profile and on cardiovascular autonomic control in ovariectomized hypertensive rats |
| Grantee: | Guilherme Lemos Shimojo Ferreira |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 13/07869-2 - Effects of the association of aerobic and resistance exercise training on autonomic and oxidative stress parameters in hypertensive ovariectomized rats |
| Grantee: | Guilherme Lemos Shimojo Ferreira |
| Support Opportunities: | Scholarships in Brazil - Master |