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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Dynamic resistance training decreases sympathetic tone in hypertensive ovariectomized rats

Full text
Author(s):
Shimojo, G. L. [1] ; Palma, R. K. [1] ; Brito, J. O. [1] ; Sanches, I. C. [1] ; Irigoyen, M. C. [2] ; De Angelis, K. [1]
Total Authors: 6
Affiliation:
[1] Univ Nove Julho, Programa Ciencias Reabilitacao, Lab Fisiol Translacional, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Fac Med, Inst Coracao, Sao Paulo, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Brazilian Journal of Medical and Biological Research; v. 48, n. 6, p. 523-527, JUN 2015.
Web of Science Citations: 10
Abstract

The aim of this study was to investigate the effects of resistance exercise training on hemodynamics and cardiac autonomic control in ovariectomized spontaneously hypertensive rats. Female rats were divided into 4 groups: sedentary control (SC), sedentary hypertensive (SH), sedentary hypertensive ovariectomized (SHO), and resistance-trained hypertensive ovariectomized (RTHO). Resistance exercise training was performed on a vertical ladder (5 days/week, 8 weeks) at 40-60% maximal load. Direct arterial pressure was recorded. Vagal and sympathetic tones were measured by heart rate (HR) responses to methylatropine (3 mg/kg, iv) and propranolol (4 mg/kg, iv). Ovariectomy resulted in additional increases in blood pressure in hypertensive rats and was associated with decreased vagal tone. Resistance exercise trained rats had lower mean arterial pressure than untrained rats (RTHO: 159 +/- 2.2 vs SHO: 177 +/- 3.4 mmHg), as well as resting bradycardia (RTHO: 332 +/- 9.0 vs SHO: 356 +/- 5 bpm). Sympathetic tone was also lower in the trained group. Moreover, sympathetic tone was positively correlated with resting HR (r=0.7, P < 0.05). The additional arterial pressure increase in hypertensive rats caused by ovarian hormone deprivation was attenuated by moderate-intensity dynamic resistance training. This benefit may be associated with resting bradycardia and reduced cardiac sympathetic tone after training, which suggests potential benefits of resistance exercise for the management of hypertension after ovarian hormone deprivation. (AU)

FAPESP's process: 12/02023-5 - Effects of resistance exercise training on hemodynamic profile and on cardiovascular autonomic control in ovariectomized hypertensive rats
Grantee:Guilherme Lemos Shimojo Ferreira
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 13/07869-2 - Effects of the association of aerobic and resistance exercise training on autonomic and oxidative stress parameters in hypertensive ovariectomized rats
Grantee:Guilherme Lemos Shimojo Ferreira
Support type: Scholarships in Brazil - Master
FAPESP's process: 11/16441-0 - Effects of aerobic or resistance exercise training on autonomic parameters and oxidative stress in ovariectomized hypertensive rats
Grantee:Renata Kelly da Palma
Support type: Scholarships in Brazil - Master
FAPESP's process: 12/20141-5 - Effects of aerobic,resistance or combined exercise training in experimental models of cardiometabolic disorders associated with ovarian hormone deprivation
Grantee:Kátia de Angelis Lobo D Avila
Support type: Regular Research Grants