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Correlation between cardiac autonomic modulation and metabolic parameters in women with polycystic ovary syndrome

Grant number: 08/08911-4
Support type:Scholarships in Brazil - Master
Effective date (Start): March 01, 2009
Effective date (End): September 30, 2009
Field of knowledge:Health Sciences - Physiotherapy and Occupational Therapy
Principal Investigator:Hugo Celso Dutra de Souza
Grantee:Nathália Sigilló Cardoso
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Women with polycystic ovary syndrome (PCOS) have high prevalence of obesity. In addition to obesity, this disease is also associated with insulin resistance and hyperinsulinemia, which increases the risk of cardiovascular diseases. Our hypothesis is based on the possibility that this endocrine-metabolic syndrome can promote relevant autonomic changes, thus impairing the cardiac autonomic control regardless of theassociated comorbidities (e.g. obesity). Therefore, our objective is to characterize theimpairment of the cardiac autonomic modulation in women with polycystic ovary syndrome according to different levels of obesity. For this reason, female volunteers aged 18 to 39 years old presenting different percentages of body fat, with or without non-treated polycystic ovary, will be submitted to analysis of cardiac autonomic modulation in association with body composition, and laboratory exams to determine serum triglyceride levels, cholesterol fractions, fasting glycaemia, glucose tolerance, insulin and insulin sensitivity, catecholamine, leptin, adiponectin, and TNF-alfa factor.