Evaluation of the Framingham risk score (FRS) and the occurrence of cardiovascular events in patients with polycystic ovary syndrome

• Grant number: 11/19369-9
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2012
• End date: April 30, 2013
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Anaglória Pontes
• Grantee: Anaglória Pontes
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

The polycystic ovary syndrome (PCOS) is a common endocrinopathy in women at reproductive age. It is characterized by hyperandrogenism, ovulatory dysfunction and infertility. It is associated with acknowledged cardiovascular risk factors: insulin resistance with compensatory hyperinsulinemia, dyslipidemias, arterial hypertension, obesity, components of the metabolic syndrome, which all increase risk for type-2 diabetes mellitus (DM2), and cardiovascular events. In an assessment, conducted by our group, on women with PCOS, 38.7% prevalence of the metabolic syndrome, 10% of glucose intolerance and 5.7% of DM2 at ages 24.6 +/- 6.4 years were observed. Although women with PCOS show a profile with adverse cardiovascular risk, only a limited number of studies confirm the association between PCOS and mortality due to cardiovascular events. Cardiovascular diseases are the main cause for morbi-mortality in the population; therefore, the present study aims at evaluating Framingham risk score and the occurrence of cardiovascular events in women with the polycystic ovary syndrome by comparing them with a group of women without that disorder (control group). To that end, 200 women in each group will be analyzed by using clinical and biochemical parameters. Framingham risk score will be applied, and the occurrence of cardiovascular events will be obtained by the analysis of medical charts and the hospital's computerized information system by crossing the names and registrations of patients treated at the Endocrine Gynecology and Sterility, Cardiology, Neurology and Vascular Surgery Outpatient Units. An active search will be conducted by telephone, if necessary. The possibility of association between PCOS and cardiovascular disease in young women with PCOS shows the need for implementing education programs for this group of women for primary prevention of modifiable cardiovascular risk factors. (AU)