Study of artificial chylomicrom metabolism in patients with the polycystic ovary syndrome

• Grant number: 05/04094-3
• Support type: Regular Research Grants
• Duration: April 01, 2006 - March 31, 2008
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal researcher: José Antonio Miguel Marcondes
• Grantee: José Antonio Miguel Marcondes
• Home Institution: Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

Dyslipidemia is recognized as a risk factor for coronary artery disease. The delayed catabolism of chylomicrons happens before changes in plasma lipids, therefore, it is an earlier marker risk factor for cardiovascular disease. We will study twenty women with polycystic ovary syndrome (PCOS), ages between 18 - 35 years( 10 obese and 10 nonobese) and twenty normal women, for age and body mass index. The diagnostic of PCOS will be do according to the Rotterdam consensus.The lipid metabolism will be study through the determination of plasm lipid and lipoproteins and the chylomicron metabolism through the plasma kinetics of a chylomicron-like emulsion and the plasma lipolytic activity through the heparin test for determination of lipoprotein and liver lipase. All the profile will be correlate with a index of insulin sensitivity derived from the oral glucose tolerance test ( the area under the curve of insulin). (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ROCHA, MICHELLE P.; MARANHAO, RAUL C.; SEYDELL, TALITA M.; BARCELLOS, CRISTIANO R. G.; BARACAT, EDMUNDO C.; HAYASHIDA, SYLVIA A. Y.; BYDLOWSKI, SERGIO P.; MARCONDES, JOSE A. M. Metabolism of triglyceride-rich lipoproteins and lipid transfer to high-density lipoprotein in young obese and normal-weight patients with polycystic ovary syndrome. Fertility and Sterility, v. 93, n. 6, p. 1948-1956, APR 2010. Web of Science Citations: 12.