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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Aerobic Training Is Better Than Resistance Training on Cardiac Function and Autonomic Modulation in Female ob/ob Mice

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Author(s):
Conti, Filipe Fernandes [1, 2] ; Irigoyen, Maria-Claudia [3] ; Sartori, Michelle [3] ; Ribeiro, Amanda Aparecida [3] ; dos Santos, Fernando [3] ; Machi, Jacqueline Freire [4, 3] ; Taboas Figueroa, Diego Mendrot [3] ; Rodrigues, Bruno [5] ; De Angelis, Katia [6, 1]
Total Authors: 9
Affiliation:
[1] Univ Nove de Julio UNINOVE, Translat Physiol Lab, Sao Paulo, SP - Brazil
[2] Nova Southeastern Univ, Coll Pharm, Hlth Profess Div, Ft Lauderdale, FL 33314 - USA
[3] Univ Sao Paulo, Med Sch, Heart Inst InCor, Hypertens Unit, Sao Paulo, SP - Brazil
[4] Univ Miami, Dept Mol & Cellular Pharmacol, Coral Gables, FL 33124 - USA
[5] Univ Estadual Campinas, Dept Adapted Phys Act, Fac Phys Educ, Campinas, SP - Brazil
[6] Fed Univ Sao Paulo UNIFESP, Dept Physiol, Sao Paulo, SP - Brazil
Total Affiliations: 6
Document type: Journal article
Source: FRONTIERS IN PHYSIOLOGY; v. 10, DEC 5 2019.
Web of Science Citations: 0
Abstract

Objective: This study evaluated the effects of aerobic, resistance, and combined exercise training on cardiac function and autonomic modulation in female ob/ob mice. Methods: Four-week-old female wild type and obese (ob/ob) mice were divided into five groups (n = 8): control (WT), obese (OB) obese + aerobic training (OBA), obese + resistance training (OBR), and obese + combined training (OBC). The exercise training was performed on treadmill and/or ladder at 40-60% maximum test during 8 weeks. Cardiac function was measured using echo machine. Heart rate variability (HRV) was evaluated in the time and frequency domain. Results: OB group presented higher body weight gain (similar to 600%), glycemia (similar to 44%) and glucose intolerance (similar to 150%), reduction of cardiac vagal modulation, evidenced by a lower RMMSD (similar to 56%), total power and high frequency band, and a higher isovolumic relaxation time (IVRT) (similar to 24%) in relation to the WT group. Aerobic and combined training led to a lower IVRT (OBA: similar to 14%; OBC: similar to 14%) and myocardial global index (OBA: similar to 37%; OBC: similar to 44%). The OBA group presented an increased in vagal indexes of HRV than the other ob/ob groups. A negative correlation was observed between the delta of aerobic exercise capacity and MPI (r = 0.45; p = 0.002) and exercise capacity and body weight gain (r = 0.39; p = 0.002). Conclusion: Only the obese females underwent to aerobic exercise training showed improvement in cardiac function and HRV. Moreover, the aerobic exercise capacity as well as a greater responsivity to aerobic exercise training is intimately associated with these improvements, reinforcing the importance of aerobic exercise training to this population. (AU)

FAPESP's process: 18/17183-4 - Fructose overload in genitors: impact of exercise training on cardiometabolic and neuroimmune changes in offspring
Grantee:Kátia de Angelis Lobo D Avila
Support type: Regular Research Grants
FAPESP's process: 10/17188-4 - Dysfunction associated mechanisms to a menopause and syndrome metabolic experimental model: role of aerobic and resistance exercise training
Grantee:Janaina de Oliveira Brito
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 18/19006-2 - ASSOCIATION BETWEEN SERUM AND FUNCTIONAL BIOMARKERS, AND IMAGE EXAMS IN DIASTOLIC AND COGNITIVE DYSFUNCTIONS
Grantee:Maria Claudia Costa Irigoyen
Support type: Regular Research Grants
FAPESP's process: 15/11223-6 - Time course of neuroimmune changes induced by chronic fructose consumption in normotensive and hypertensive rats: role of aerobic exercise training
Grantee:Kátia de Angelis Lobo D Avila
Support type: Regular Research Grants
FAPESP's process: 11/15828-9 - Effects of combined exercise training in an experimental model of cardiometabolic disorders associated with ovarian hormone deprivation.
Grantee:Filipe Fernandes Conti
Support type: Scholarships in Brazil - Master