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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cardiovascular autonomic dysfunction and oxidative stress induced by fructose overload in an experimental model of hypertension and menopause

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Conti, Filipe Fernandes [1] ; Brito, Janaina de Oliveira [1] ; Bernardes, Nathalia [2] ; Dias, Danielle da Silva [1] ; Sanches, Iris Callado [1] ; Malfitano, Christiane [1] ; Francisca Llesuy, Susana [3] ; Irigoyen, Maria-Claudia [2] ; de Angelis, Katia [1]
Total Authors: 9
[1] Univ Nove de Julho UNINOVE, Lab Translat Physiol, Sao Paulo - Brazil
[2] Univ Sao Paulo, Heart Inst InCor, Sch Med, Hypertens Unit, Sao Paulo - Brazil
[3] Univ Buenos Aires, Fac Farm & Bioquim, Dept Quim Analit & Fisicoquim, RA-1113 Buenos Aires, DF - Argentina
Total Affiliations: 3
Document type: Journal article
Web of Science Citations: 14

Background: Metabolic syndrome is characterized by the association of 3 or more risk factors, including: abdominal obesity associated with an excess of abdominal fat, insulin resistance, type 2 diabetes, dyslipidemia and hypertension. Moreover, the prevalence of hypertension and metabolic dysfunctions sharply increases after the menopause. However, the mechanisms involved in these changes are not well understood. Thus, the aim of this study was to assess the effects of fructose overload on cardiovascular autonomic modulation, inflammation and cardiac oxidative stress in an experimental model of hypertension and menopause. Methods: Female SHR rats were divided into (n = 8/group): hypertensive (H), hypertensive ovariectomized (HO) and hypertensive ovariectomized undergoing fructose overload (100 g/L in drinking water) (FHO). Arterial pressure (AP) signals were directly recorded. Cardiac autonomic modulation was evaluated by spectral analysis. Oxidative stress was evaluated in cardiac tissue. Results: AP was higher in the FHO group when compared to the other groups. Fructose overload promoted an increase in body and fat weight, triglyceride concentration and a reduction in insulin sensitivity. IL-10 was reduced in the FHO group when compared to the H group. TNF-alpha was higher in the FHO when compared to all other groups. Lipoperoxidation was higher and glutathione redox balance was reduced in the FHO group when compared to other groups, an indication of increased oxidative stress. A negative correlation was found between IL-10 and adipose tissue. Conclusion: Fructose overload promoted an impairment in cardiac autonomic modulation associated with inflammation and oxidative stress in hypertensive rats undergoing ovarian hormone deprivation. (AU)

FAPESP's process: 11/15828-9 - Effects of combined exercise training in an experimental model of cardiometabolic disorders associated with ovarian hormone deprivation.
Grantee:Filipe Fernandes Conti
Support type: Scholarships in Brazil - Master
FAPESP's process: 12/20141-5 - Effects of aerobic,resistance or combined exercise training in experimental models of cardiometabolic disorders associated with ovarian hormone deprivation
Grantee:Kátia de Angelis Lobo D Avila
Support type: Regular Research Grants
FAPESP's process: 10/17188-4 - Dysfunction associated mechanisms to a menopause and syndrome metabolic experimental model: role of aerobic and resistance exercise training
Grantee:Janaina de Oliveira Brito
Support type: Scholarships in Brazil - Doctorate