Fluconazole Non-susceptible Cryptococcus neoformans, Relapsing/Refractory Cryptococcosis and Long-term Use of Liposomal Amphotericin B in an AIDS Patient

Autor(es)

Santana, Rodrigo de Carvalho ; Schiave, Leticia Aparecida ; dos Santos Quaglio, Alda Soares ; de Gaitani, Cristiane Masetto ; Martinez, Roberto

• Tipo de documento: Artigo Científico
• Fonte: Mycopathologia; v. 182, n. 9-10, p. 855-861, OCT 2017.
• Citações Web of Science: 2

Resumo

The treatment of cryptococcosis is hampered by inefficacy or intolerance to the recommended antifungal agents. A patient diagnosed with AIDS had multiple relapses of cryptococcal infection, which became refractory to antifungal agents during the course of therapy. During the follow-up, the patient developed renal toxicity due to amphotericin B use and non-susceptibility of isolated Cryptococcus neoformans to fluconazole was detected. Thereafter, antifungal treatment was performed exclusively with liposomal amphotericin B, reaching a cumulative dose of 19,180 mg over 46 months. The final relapse of cryptococcosis occurred during the maintenance phase with liposomal formulation in a once-weekly dose. Measurement of the minimum serum concentrations of amphotericin B, determined sequentially before and after this relapse, suggested the importance of monitoring drug levels when the liposomal formulation is used for a long period. (AU)

• Processo FAPESP: 12/51030-4 - Associação da resposta terapêutica e níveis de anfotericina B e de fluconazol em diferentes amostras biológicas de pacientes com infecção fúngica do sistema nervoso central
• Beneficiário: Letícia Aparecida Schiave
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado