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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Fluconazole Non-susceptible Cryptococcus neoformans, Relapsing/Refractory Cryptococcosis and Long-term Use of Liposomal Amphotericin B in an AIDS Patient

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Author(s):
Santana, Rodrigo de Carvalho ; Schiave, Leticia Aparecida ; dos Santos Quaglio, Alda Soares ; de Gaitani, Cristiane Masetto ; Martinez, Roberto
Total Authors: 5
Document type: Journal article
Source: Mycopathologia; v. 182, n. 9-10, p. 855-861, OCT 2017.
Web of Science Citations: 2
Abstract

The treatment of cryptococcosis is hampered by inefficacy or intolerance to the recommended antifungal agents. A patient diagnosed with AIDS had multiple relapses of cryptococcal infection, which became refractory to antifungal agents during the course of therapy. During the follow-up, the patient developed renal toxicity due to amphotericin B use and non-susceptibility of isolated Cryptococcus neoformans to fluconazole was detected. Thereafter, antifungal treatment was performed exclusively with liposomal amphotericin B, reaching a cumulative dose of 19,180 mg over 46 months. The final relapse of cryptococcosis occurred during the maintenance phase with liposomal formulation in a once-weekly dose. Measurement of the minimum serum concentrations of amphotericin B, determined sequentially before and after this relapse, suggested the importance of monitoring drug levels when the liposomal formulation is used for a long period. (AU)

FAPESP's process: 12/51030-4 - Association of therapeutic response and levels of amphotericin B and fluconazole in different biological samples of fungal infections of the central nervous system patients
Grantee:Letícia Aparecida Schiave
Support type: Scholarships in Brazil - Post-Doctorate