Interactions between sleep, stress, and metabolism: From physiological to pathological conditions

Autor(es)

Hirotsu, Camila ; Tufik, Sergio ; Andersen, Monica Levy

• Tipo de documento: Artigo de Revisão
• Fonte: SLEEP SCIENCE; v. 8, n. 3, p. 143-152, NOV 2015.
• Citações Web of Science: 45

Resumo

Poor sleep quality due to sleep disorders and sleep loss is highly prevalent in the modern society. Underlying mechanisms show that stress is involved in the relationship between sleep and metabolism through hypothalamicpituitaryadrenal (HPA) axis activation. Sleep deprivation and sleep disorders are associated with maladaptive changes in the HPA axis, leading to neuroendocrine dysregulation. Excess of glucocorticoids increase glucose and insulin and decrease adiponectin levels. Thus, this review provides overall view of the relationship between sleep, stress, and metabolism from basic physiology to pathological conditions, highlighting effective treatments for metabolic disturbances. (C) 2015 Brazilian Associationof Sleep. Production and Hosting by Elsevier B.V. (AU)

• Processo FAPESP: 14/15259-2 - Epidemiologia do sono na cidade de São Paulo: seguimento dos voluntários do estudo de base EPISONO
• Beneficiário: Camila Hirotsu
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado