Emergence of Trichosporon mycotoxinivorans (Apiotr... - BV FAPESP
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Emergence of Trichosporon mycotoxinivorans (Apiotrichum mycotoxinivorans) invasive infections in Latin America

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Autor(es):
de Almeida, Jr., Joao Nobrega [1, 2] ; Francisco, Elaine Cristina [3] ; de Andrade Barberino, Maria Goreth M. [4] ; da Silva Filho, Luiz Vicente Ribeiro F. [5] ; Brandao, Oriana M. [6] ; Colombo, Arnaldo Lopes [3] ; Barbosa Padovan, Ana Carolina [7]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Inst Med Trop, Div Lab Cent LIM03, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Fac Med, Hosp Clin, Lab Micol Med LIM53, Sao Paulo, SP - Brazil
[3] Univ Fed Sao Paulo, Escola Paulista Med, Lab Especial Micol, Sao Paulo, SP - Brazil
[4] Univ Fed Bahia, Complexo Hosp Univ Prof Edgar Santos, Lab Microbiol, Salvador, BA - Brazil
[5] Univ Sao Paulo, Fac Med, Hosp Clin, Inst Crianca, Sao Paulo, SP - Brazil
[6] Univ Fed Bahia, Dept Med, Complexo Hosp Univ Prof Edgar Santos, Salvador, BA - Brazil
[7] Univ Fed Alfenas, Dept Microbiol & Imunol, Alfenas, MG - Brazil
Número total de Afiliações: 7
Tipo de documento: Artigo Científico
Fonte: Memórias do Instituto Oswaldo Cruz; v. 112, n. 10, p. 719-722, OCT 2017.
Citações Web of Science: 4
Resumo

We report the first two cases of Trichosporon mycotoxinivorans infections in Latin America. We also conducted a literature review and a microbiological investigation, including that of clinical and environmental isolates. A 30-year-old man with chronic renal failure had disseminated infection after dialysis and a 15-year-old boy with cystic fibrosis (CF) had pulmonary exacerbations with positive respiratory samples. A review of the relevant literature revealed that deep-seated infections were related to immunosuppression or invasive devices, while most of the CF patients showed a decline in lung function after positive cultures. Phylogenetic analyses revealed three distinct circulating genotypes. MALDI-TOF mass spectrometry analysis showed similar spectral profiles and correctly identified all strains/isolates. Biofilm production was documented in a bloodstream isolate and biofilm-producing cells showed high minimum inhibitory concentrations against antifungals. (AU)

Processo FAPESP: 14/10126-4 - Caracterização clínico-microbiológica de isolados clínicos de leveduras pertencentes ao complexo Candida haemulonii no HC-FMUSP
Beneficiário:João Nóbrega de Almeida Júnior
Modalidade de apoio: Auxílio à Pesquisa - Regular