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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Emergence of Trichosporon mycotoxinivorans (Apiotrichum mycotoxinivorans) invasive infections in Latin America

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Author(s):
de Almeida, Jr., Joao Nobrega [1, 2] ; Francisco, Elaine Cristina [3] ; de Andrade Barberino, Maria Goreth M. [4] ; da Silva Filho, Luiz Vicente Ribeiro F. [5] ; Brandao, Oriana M. [6] ; Colombo, Arnaldo Lopes [3] ; Barbosa Padovan, Ana Carolina [7]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Inst Med Trop, Div Lab Cent LIM03, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Fac Med, Hosp Clin, Lab Micol Med LIM53, Sao Paulo, SP - Brazil
[3] Univ Fed Sao Paulo, Escola Paulista Med, Lab Especial Micol, Sao Paulo, SP - Brazil
[4] Univ Fed Bahia, Complexo Hosp Univ Prof Edgar Santos, Lab Microbiol, Salvador, BA - Brazil
[5] Univ Sao Paulo, Fac Med, Hosp Clin, Inst Crianca, Sao Paulo, SP - Brazil
[6] Univ Fed Bahia, Dept Med, Complexo Hosp Univ Prof Edgar Santos, Salvador, BA - Brazil
[7] Univ Fed Alfenas, Dept Microbiol & Imunol, Alfenas, MG - Brazil
Total Affiliations: 7
Document type: Journal article
Source: Memórias do Instituto Oswaldo Cruz; v. 112, n. 10, p. 719-722, OCT 2017.
Web of Science Citations: 4
Abstract

We report the first two cases of Trichosporon mycotoxinivorans infections in Latin America. We also conducted a literature review and a microbiological investigation, including that of clinical and environmental isolates. A 30-year-old man with chronic renal failure had disseminated infection after dialysis and a 15-year-old boy with cystic fibrosis (CF) had pulmonary exacerbations with positive respiratory samples. A review of the relevant literature revealed that deep-seated infections were related to immunosuppression or invasive devices, while most of the CF patients showed a decline in lung function after positive cultures. Phylogenetic analyses revealed three distinct circulating genotypes. MALDI-TOF mass spectrometry analysis showed similar spectral profiles and correctly identified all strains/isolates. Biofilm production was documented in a bloodstream isolate and biofilm-producing cells showed high minimum inhibitory concentrations against antifungals. (AU)

FAPESP's process: 14/10126-4 - Clinical and microbiological features of Candida haemulonii complex isolates from HC-FMUSP
Grantee:João Nóbrega de Almeida Júnior
Support Opportunities: Regular Research Grants