Melatonin, mitochondria and hypertension

Autor(es)

Baltatu, Ovidiu C. ^[1] ; Amaral, Fernanda G. ^[2] ; Campos, Luciana A. ^[1] ; Cipolla-Neto, Jose ^[3]

Afiliação do(s) autor(es)

^[1] Laureate Int Univ, Anhembi Morumbi Univ, CITE, 500 Dr Altino Bondensan Ave, BR-12247016 Sao Jose Dos Campos, SP - Brazil

^[2] Univ Fed Sao Paulo, Dept Physiol, 862 Botucatu St, 5th Floor, BR-04023901 Sao Paulo, SP - Brazil

^[3] Univ Sao Paulo, Dept Physiol, Inst Biomed Sci, Av Lineu Prestes 1524, Room 115-118, BR-05508000 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: CELLULAR AND MOLECULAR LIFE SCIENCES; v. 74, n. 21, p. 3955-3964, NOV 2017.
• Citações Web of Science: 14

Resumo

Melatonin, due to its multiple means and mechanisms of action, plays a fundamental role in the regulation of the organismal physiology by fine tunning several functions. The cardiovascular system is an important site of action as melatonin regulates blood pressure both by central and peripheral interventions, in addition to its relation with the renin-angiotensin system. Besides, the systemic management of several processes, melatonin acts on mitochondria regulation to maintain a healthy cardiovascular system. Hypertension affects target organs in different ways and cellular energy metabolism is frequently involved due to mitochondrial alterations that include a rise in reactive oxygen species production and an ATP synthesis decrease. The discussion that follows shows the role played by melatonin in the regulation of mitochondrial physiology in several levels of the cardiovascular system, including brain, heart, kidney, blood vessels and, particularly, regulating the renin-angiotensin system. This discussion shows the putative importance of using melatonin as a therapeutic tool involving its antioxidant potential and its action on mitochondrial physiology in the cardiovascular system. (AU)

• Processo FAPESP: 14/50457-0 - Melatonina e a regulação do metabolismo energético: estudos básicos, clínicos e epidemiológicos
• Beneficiário: José Cipolla Neto
• Modalidade de apoio: Auxílio à Pesquisa - Temático