Childhood adversities and post-traumatic stress disorder: evidence for stress sensitisation in the World Mental Health Surveys

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McLaughlin, Katie A. ^[1] ; Koenen, Karestan C. ^[2] ; Bromet, Evelyn J. ^[3] ; Karam, Elie G. ^{[4, 5, 6]} ; Liu, Howard ^[7] ; Petukhova, Maria ^[7] ; Ruscio, Ayelet Meron ^[8] ; Sampson, Nancy A. ^[7] ; Stein, Dan J. ^[9] ; Aguilar-Gaxiola, Sergio ^[10] ; Alonso, Jordi ^{[11, 12]} ; Borges, Guilherme ^[13] ; Demyttenaere, Koen ^[14] ; Dinolova, Rumyana V. ^[15] ; Ferry, Finola ^[16] ; Florescu, Silvia ^[17] ; de Girolamo, Giovanni ^[18] ; Gureje, Oye ^[19] ; Kawakami, Narito ^[20] ; Lee, Sing ^[21] ; Navarro-Mateu, Fernando ^{[22, 23, 24]} ; Piazza, Marina ^{[25, 26]} ; Pennell, Beth-Ellen ^[27] ; Posada-Villa, Jose ^[28] ; ten Have, Margreet ^[29] ; Viana, Maria Carmen ^[30] ; Kessler, Ronald C. ^[7]

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^[1] Univ Washington, Dept Psychol, Box 351525, Seattle, WA 98195 - USA

^[2] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA - USA

^[3] SUNY Stony Brook, Sch Med, Dept Psychiat, Stony Brook, NY 11794 - USA

^[4] Balamand Univ, Fac Med, Dept Psychiat & Clin Psychol, Beirut - Lebanon

^[5] St George Hosp Univ, Med Ctr, Dept Psychiat & Clin Psychol, Beirut - Lebanon

^[6] Inst Dev Res Advocacy & Appl Care, Beirut - Lebanon

^[7] Harvard Med Sch, Dept Hlth Care Policy, Boston, MA - USA

^[8] Univ Penn, Dept Psychol, Philadelphia, PA - USA

^[9] Univ Cape Town, Dept Psychiat & Mental Hlth, Cape Town - South Africa

^[10] UC Davis Hlth Syst, Ctr Reducing Hlth Dispar, Sacramento, CA - USA

^[11] Pompeu Fabra Univ UPF, Parc Salut Mar Barcelona, IMIM Hosp Mar Res Inst, Barcelona - Spain

^[12] CIBER Epidemiol Salud Publ CIBERESP, Barcelona - Spain

^[13] Inst Nacl Psiquiat, San Lorenzo - Mexico

^[14] Katholieke Univ Leuven, Univ Hosp Gasthuisberg, Dept Psychiat, Leuven - Belgium

^[15] Natl Ctr Publ Hlth & Analyses, Sofia - Bulgaria

^[16] Univ Ulster, Bamford Ctr Mental Hlth & Wellbeing, Coleraine, Londonderry - North Ireland

^[17] Natl Sch Publ Hlth Management & Dev, Bucharest - Romania

^[18] IRCCS, St John God Clin Res Ctr, Unit Epidemiol & Evaluat Psychiat, Brescia - Italy

^[19] Univ Coll Hosp, Dept Psychiat, Ibadan - Nigeria

^[20] Univ Tokyo, Sch Publ Hlth, Dept Mental Hlth, Tokyo - Japan

^[21] Chinese Univ Hong Kong, Dept Psychiat, Tai Po, Hong Kong - Peoples R China

^[22] Serv Murciano Salud, Subdirecc Gen Planificac Innovat & Cronicidad, UDIF SM, Murcia - Spain

^[23] IMIB Arrixaca, Murcia - Spain

^[24] CIBERESP Murcia, Murcia - Spain

^[25] Natl Inst Hlth, Lima - Peru

^[26] Univ Cayetano Heredia, Lima - Peru

^[27] Univ Michigan, Inst Social Res, Survey Res Ctr, Ann Arbor, MI 48109 - USA

^[28] Cundinamarca Univ, Fac Social Sci Colegio Mayor, Bogota - Colombia

^[29] Netherlands Inst Mental Hlth & Addict, Trimbos Inst, Utrecht - Netherlands

^[30] Univ Fed Espirito Santo, Dept Social Med, Vitoria - Brazil

• Tipo de documento: Artigo Científico
• Fonte: BRITISH JOURNAL OF PSYCHIATRY; v. 211, n. 5, p. 280+, NOV 2017.
• Citações Web of Science: 18

Resumo

Background Although childhood adversities are known to predict increased risk of post-traumatic stress disorder (PTSD) after traumatic experiences, it is unclear whether this association varies by childhood adversity or traumatic experience types or by age. Aims To examine variation in associations of childhood adversities with PTSD according to childhood adversity types, traumatic experience types and life-course stage. Method Epidemiological data were analysed from the World Mental Health Surveys (n=27017). Results Four childhood adversities (physical and sexual abuse, neglect, parent psychopathology) were associated with similarly increased odds of PTSD following traumatic experiences (odds ratio (OR)=1.8), whereas the other eight childhood adversities assessed did not predict PTSD. Childhood adversity-PTSD associations did not vary across traumatic experience types, but were stronger in childhood-adolescence and early middle adulthood than later adulthood. Conclusions Childhood adversities are differentially associated with PTSD, with the strongest associations in childhood-adolescence and early-middle adulthood. Consistency of associations across traumatic experience types suggests that childhood adversities are associated with generalised vulnerability to PTSD following traumatic experiences. (AU)

• Processo FAPESP: 03/00204-3 - Estudo epidemiológico dos transtornos psiquiátricos na região metropolitana de São Paulo: prevalências, fatores de risco e sobrecarga social e econômica
• Beneficiário: Laura Helena Silveira Guerra de Andrade
• Modalidade de apoio: Auxílio à Pesquisa - Temático