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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Alcohol and cigarette consumption predict mortality in patients with head and neck cancer: a pooled analysis within the International Head and Neck Cancer Epidemiology (INHANCE) Consortium

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Autor(es):
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Giraldi, L. [1] ; Leoncini, E. [1] ; Pastorino, R. [1] ; Wunsch-Filho, V. [2] ; de Carvalho, M. [3] ; Lopez, R. [4] ; Cadoni, G. [5] ; Arzani, D. [1] ; Petrelli, L. [5] ; Matsuo, K. [6] ; Bosetti, C. [7] ; La Vecchia, C. [8] ; Garavello, W. [9] ; Polesel, J. [10] ; Serraino, D. [10] ; Simonato, L. [11] ; Canova, C. [12] ; Richiardi, L. [13] ; Boffetta, P. [14, 15] ; Hashibe, M. [16, 17] ; Lee, Y. C. A. [16] ; Boccia, S. [18]
Número total de Autores: 22
Afiliação do(s) autor(es):
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[1] Univ Cattolica Sacro Cuore, Inst Publ Hlth, Sect Hyg, Largo F Vito 1, I-00168 Rome - Italy
[2] Univ Sao Paulo, Publ Hlth, Sao Paulo - Brazil
[3] Heliopolis Hosp, Dept Head & Neck, Sao Paulo - Brazil
[4] Canc Inst State Sao Paulo, Sao Paulo - Brazil
[5] Univ Cattolica Sacro Cuore, Inst Otorhinolaryngol, Rome - Italy
[6] Aichi Canc Ctr Res Inst, Nagoya, Aichi - Japan
[7] IRCCS Ist Ric Farmacol Mario Negri, Dept Epidemiol, Milan - Italy
[8] Univ Milan, Dept Clin Sci & Community Hlth, Milan - Italy
[9] Univ Milano Bicocca, Sch Med & Surg, Milan - Italy
[10] CRO Aviano Natl Canc Inst, Unit Canc Epidemiol, Aviano - Italy
[11] Univ Padua, Dept Cardiol Vasc Thorac Sci & Publ Hlth, Padua - Italy
[12] Univ Padua, Dept Mol Med, Padua - Italy
[13] Univ Turin, Dept Med Sci, Turin - Italy
[14] Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY 10029 - USA
[15] Icahn Sch Med Mt Sinai, Inst Translat Epidemiol, New York, NY 10029 - USA
[16] Univ Utah, Sch Med, Dept Family & Prevent Med, Div Publ Hlth, Salt Lake City, UT - USA
[17] Univ Utah, Sch Med, Huntsman Canc Inst, Salt Lake City, UT - USA
[18] Univ Cattolica Sacro Cuore, Fdn Policlin A Gemelli, Inst Publ Hlth, Sect Hyg, Rome - Italy
Número total de Afiliações: 18
Tipo de documento: Artigo Científico
Fonte: Annals of Oncology; v. 28, n. 11, p. 2843-2851, NOV 2017.
Citações Web of Science: 11
Resumo

This study evaluated whether demographics, pre-diagnosis lifestyle habits and clinical data are associated with the overall survival (OS) and head and neck cancer (HNC)-specific survival in patients with HNC. We conducted a pooled analysis, including 4759 HNC patients from five studies within the International Head and Neck Cancer Epidemiology (INHANCE) Consortium. Cox proportional hazard ratios (HRs) and the corresponding 95% confidence intervals (CIs) were estimated including terms reported significantly associated with the survival in the univariate analysis. Five-year OS was 51.4% for all HNC sites combined: 50.3% for oral cavity, 41.1% for oropharynx, 35.0% for hypopharynx and 63.9% for larynx. When we considered HNC-specific survival, 5-year survival rates were 57.4% for all HNC combined: 54.6% for oral cavity, 45.4% for oropharynx, 37.1% for hypopharynx and 72.3% for larynx. Older ages at diagnosis and advanced tumour staging were unfavourable predictors of OS and HNC-specific survival. In laryngeal cancer, low educational level was an unfavourable prognostic factor for OS (HR = 2.54, 95% CI 1.01-6.38, for high school or lower versus college graduate), and status and intensity of alcohol drinking were prognostic factors both of the OS (current drinkers HR = 1.73, 95% CI 1.16-2.58) and HNC-specific survival (current drinkers HR = 2.11, 95% CI 1.22-3.66). In oropharyngeal cancer, smoking status was an independent prognostic factors for OS. Smoking intensity (> 20 cigarettes/day HR = 1.41, 95% CI 1.03-1.92) was also an independent prognostic factor for OS in patients with cancer of the oral cavity. OS and HNC-specific survival differ among HNC sites. Pre-diagnosis cigarette smoking is a prognostic factor of the OS for patients with cancer of the oral cavity and oropharynx, whereas pre-diagnosis alcohol drinking is a prognostic factor of OS and HNC-specific survival for patients with cancer of the larynx. Low educational level is an unfavourable prognostic factor for OS in laryngeal cancer patients. (AU)

Processo FAPESP: 04/12054-9 - Busca de marcadores de agressividade em tumores de cabeça e pescoço
Beneficiário:Eloiza Helena Tajara da Silva
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 10/51168-0 - Fatores ambientais, clínicos, histopatológicos e moleculares associados ao desenvolvimento e ao prognóstico de carcinomas epidermoides de cabeça e pescoço
Beneficiário:Eloiza Helena Tajara da Silva
Linha de fomento: Auxílio à Pesquisa - Temático