Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Alcohol and cigarette consumption predict mortality in patients with head and neck cancer: a pooled analysis within the International Head and Neck Cancer Epidemiology (INHANCE) Consortium

Full text
Author(s):
Show less -
Giraldi, L. [1] ; Leoncini, E. [1] ; Pastorino, R. [1] ; Wunsch-Filho, V. [2] ; de Carvalho, M. [3] ; Lopez, R. [4] ; Cadoni, G. [5] ; Arzani, D. [1] ; Petrelli, L. [5] ; Matsuo, K. [6] ; Bosetti, C. [7] ; La Vecchia, C. [8] ; Garavello, W. [9] ; Polesel, J. [10] ; Serraino, D. [10] ; Simonato, L. [11] ; Canova, C. [12] ; Richiardi, L. [13] ; Boffetta, P. [14, 15] ; Hashibe, M. [16, 17] ; Lee, Y. C. A. [16] ; Boccia, S. [18]
Total Authors: 22
Affiliation:
Show less -
[1] Univ Cattolica Sacro Cuore, Inst Publ Hlth, Sect Hyg, Largo F Vito 1, I-00168 Rome - Italy
[2] Univ Sao Paulo, Publ Hlth, Sao Paulo - Brazil
[3] Heliopolis Hosp, Dept Head & Neck, Sao Paulo - Brazil
[4] Canc Inst State Sao Paulo, Sao Paulo - Brazil
[5] Univ Cattolica Sacro Cuore, Inst Otorhinolaryngol, Rome - Italy
[6] Aichi Canc Ctr Res Inst, Nagoya, Aichi - Japan
[7] IRCCS Ist Ric Farmacol Mario Negri, Dept Epidemiol, Milan - Italy
[8] Univ Milan, Dept Clin Sci & Community Hlth, Milan - Italy
[9] Univ Milano Bicocca, Sch Med & Surg, Milan - Italy
[10] CRO Aviano Natl Canc Inst, Unit Canc Epidemiol, Aviano - Italy
[11] Univ Padua, Dept Cardiol Vasc Thorac Sci & Publ Hlth, Padua - Italy
[12] Univ Padua, Dept Mol Med, Padua - Italy
[13] Univ Turin, Dept Med Sci, Turin - Italy
[14] Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY 10029 - USA
[15] Icahn Sch Med Mt Sinai, Inst Translat Epidemiol, New York, NY 10029 - USA
[16] Univ Utah, Sch Med, Dept Family & Prevent Med, Div Publ Hlth, Salt Lake City, UT - USA
[17] Univ Utah, Sch Med, Huntsman Canc Inst, Salt Lake City, UT - USA
[18] Univ Cattolica Sacro Cuore, Fdn Policlin A Gemelli, Inst Publ Hlth, Sect Hyg, Rome - Italy
Total Affiliations: 18
Document type: Journal article
Source: Annals of Oncology; v. 28, n. 11, p. 2843-2851, NOV 2017.
Web of Science Citations: 17
Abstract

This study evaluated whether demographics, pre-diagnosis lifestyle habits and clinical data are associated with the overall survival (OS) and head and neck cancer (HNC)-specific survival in patients with HNC. We conducted a pooled analysis, including 4759 HNC patients from five studies within the International Head and Neck Cancer Epidemiology (INHANCE) Consortium. Cox proportional hazard ratios (HRs) and the corresponding 95% confidence intervals (CIs) were estimated including terms reported significantly associated with the survival in the univariate analysis. Five-year OS was 51.4% for all HNC sites combined: 50.3% for oral cavity, 41.1% for oropharynx, 35.0% for hypopharynx and 63.9% for larynx. When we considered HNC-specific survival, 5-year survival rates were 57.4% for all HNC combined: 54.6% for oral cavity, 45.4% for oropharynx, 37.1% for hypopharynx and 72.3% for larynx. Older ages at diagnosis and advanced tumour staging were unfavourable predictors of OS and HNC-specific survival. In laryngeal cancer, low educational level was an unfavourable prognostic factor for OS (HR = 2.54, 95% CI 1.01-6.38, for high school or lower versus college graduate), and status and intensity of alcohol drinking were prognostic factors both of the OS (current drinkers HR = 1.73, 95% CI 1.16-2.58) and HNC-specific survival (current drinkers HR = 2.11, 95% CI 1.22-3.66). In oropharyngeal cancer, smoking status was an independent prognostic factors for OS. Smoking intensity (> 20 cigarettes/day HR = 1.41, 95% CI 1.03-1.92) was also an independent prognostic factor for OS in patients with cancer of the oral cavity. OS and HNC-specific survival differ among HNC sites. Pre-diagnosis cigarette smoking is a prognostic factor of the OS for patients with cancer of the oral cavity and oropharynx, whereas pre-diagnosis alcohol drinking is a prognostic factor of OS and HNC-specific survival for patients with cancer of the larynx. Low educational level is an unfavourable prognostic factor for OS in laryngeal cancer patients. (AU)

FAPESP's process: 10/51168-0 - Environmental, clinical, histopathological and molecular factors associated with development and prognosis of head and neck squamous cell carcinomas
Grantee:Eloiza Helena Tajara da Silva
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 04/12054-9 - Markers of aggressive behavior in head and neck tumors
Grantee:Eloiza Helena Tajara da Silva
Support Opportunities: Research Projects - Thematic Grants