Lifestyle factors, diet, family history of cancer and the risk of head and neck ca...
| Full text | |
| Author(s): Show less - |
Giraldi, L.
[1]
;
Leoncini, E.
[1]
;
Pastorino, R.
[1]
;
Wunsch-Filho, V.
[2]
;
de Carvalho, M.
[3]
;
Lopez, R.
[4]
;
Cadoni, G.
[5]
;
Arzani, D.
[1]
;
Petrelli, L.
[5]
;
Matsuo, K.
[6]
;
Bosetti, C.
[7]
;
La Vecchia, C.
[8]
;
Garavello, W.
[9]
;
Polesel, J.
[10]
;
Serraino, D.
[10]
;
Simonato, L.
[11]
;
Canova, C.
[12]
;
Richiardi, L.
[13]
;
Boffetta, P.
[14, 15]
;
Hashibe, M.
[16, 17]
;
Lee, Y. C. A.
[16]
;
Boccia, S.
[18]
Total Authors: 22
|
| Affiliation: Show less - | [1] Univ Cattolica Sacro Cuore, Inst Publ Hlth, Sect Hyg, Largo F Vito 1, I-00168 Rome - Italy
[2] Univ Sao Paulo, Publ Hlth, Sao Paulo - Brazil
[3] Heliopolis Hosp, Dept Head & Neck, Sao Paulo - Brazil
[4] Canc Inst State Sao Paulo, Sao Paulo - Brazil
[5] Univ Cattolica Sacro Cuore, Inst Otorhinolaryngol, Rome - Italy
[6] Aichi Canc Ctr Res Inst, Nagoya, Aichi - Japan
[7] IRCCS Ist Ric Farmacol Mario Negri, Dept Epidemiol, Milan - Italy
[8] Univ Milan, Dept Clin Sci & Community Hlth, Milan - Italy
[9] Univ Milano Bicocca, Sch Med & Surg, Milan - Italy
[10] CRO Aviano Natl Canc Inst, Unit Canc Epidemiol, Aviano - Italy
[11] Univ Padua, Dept Cardiol Vasc Thorac Sci & Publ Hlth, Padua - Italy
[12] Univ Padua, Dept Mol Med, Padua - Italy
[13] Univ Turin, Dept Med Sci, Turin - Italy
[14] Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY 10029 - USA
[15] Icahn Sch Med Mt Sinai, Inst Translat Epidemiol, New York, NY 10029 - USA
[16] Univ Utah, Sch Med, Dept Family & Prevent Med, Div Publ Hlth, Salt Lake City, UT - USA
[17] Univ Utah, Sch Med, Huntsman Canc Inst, Salt Lake City, UT - USA
[18] Univ Cattolica Sacro Cuore, Fdn Policlin A Gemelli, Inst Publ Hlth, Sect Hyg, Rome - Italy
Total Affiliations: 18
|
| Document type: | Journal article |
| Source: | Annals of Oncology; v. 28, n. 11, p. 2843-2851, NOV 2017. |
| Web of Science Citations: | 17 |
| Abstract | |
This study evaluated whether demographics, pre-diagnosis lifestyle habits and clinical data are associated with the overall survival (OS) and head and neck cancer (HNC)-specific survival in patients with HNC. We conducted a pooled analysis, including 4759 HNC patients from five studies within the International Head and Neck Cancer Epidemiology (INHANCE) Consortium. Cox proportional hazard ratios (HRs) and the corresponding 95% confidence intervals (CIs) were estimated including terms reported significantly associated with the survival in the univariate analysis. Five-year OS was 51.4% for all HNC sites combined: 50.3% for oral cavity, 41.1% for oropharynx, 35.0% for hypopharynx and 63.9% for larynx. When we considered HNC-specific survival, 5-year survival rates were 57.4% for all HNC combined: 54.6% for oral cavity, 45.4% for oropharynx, 37.1% for hypopharynx and 72.3% for larynx. Older ages at diagnosis and advanced tumour staging were unfavourable predictors of OS and HNC-specific survival. In laryngeal cancer, low educational level was an unfavourable prognostic factor for OS (HR = 2.54, 95% CI 1.01-6.38, for high school or lower versus college graduate), and status and intensity of alcohol drinking were prognostic factors both of the OS (current drinkers HR = 1.73, 95% CI 1.16-2.58) and HNC-specific survival (current drinkers HR = 2.11, 95% CI 1.22-3.66). In oropharyngeal cancer, smoking status was an independent prognostic factors for OS. Smoking intensity (> 20 cigarettes/day HR = 1.41, 95% CI 1.03-1.92) was also an independent prognostic factor for OS in patients with cancer of the oral cavity. OS and HNC-specific survival differ among HNC sites. Pre-diagnosis cigarette smoking is a prognostic factor of the OS for patients with cancer of the oral cavity and oropharynx, whereas pre-diagnosis alcohol drinking is a prognostic factor of OS and HNC-specific survival for patients with cancer of the larynx. Low educational level is an unfavourable prognostic factor for OS in laryngeal cancer patients. (AU) | |
| FAPESP's process: | 04/12054-9 - Markers of aggressive behavior in head and neck tumors |
| Grantee: | Eloiza Helena Tajara da Silva |
| Support type: | Research Projects - Thematic Grants |
| FAPESP's process: | 10/51168-0 - Environmental, clinical, histopathological and molecular factors associated with development and prognosis of head and neck squamous cell carcinomas |
| Grantee: | Eloiza Helena Tajara da Silva |
| Support type: | Research Projects - Thematic Grants |