Synthesis of alpha-amino-1,3-dicarbonyl compounds via Ugi flow chemistry reaction: access to functionalized 1,2,3-triazoles

Autor(es)

Vasconcelos, Stanley N. S. ^[1] ; Fornari, Evelin ^[1] ; Caracelli, Ignez ^[2] ; Stefani, Helio A. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Farm, Sao Paulo, SP - Brazil

^[2] Univ Fed Sao Carlos, Dept Fis, Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: MOLECULAR DIVERSITY; v. 21, n. 4, p. 893-902, NOV 2017.
• Citações Web of Science: 1

Resumo

The Ugi multicomponent reaction has been used as an important synthetic route to obtain compounds with potential biological activity. We present the rapid and efficient synthesis of -amino-1,3-dicarbonyl compounds in moderate to good yields via Ugi flow chemistry reactions performed with a continuous flow reactor. Such -amino-1,3-dicarbonyl compounds can act as precursors for the production of -amino acids via hydrolysis of the ethyl ester group as well as building blocks for the synthesis of novel compounds with the 1,2,3-triazole ring. The -amino acid derivatives of the Ugi flow chemistry reaction products were then used for dipeptide synthesis. (AU)

• Processo FAPESP: 13/17960-7 - Funcionalização da 3-Iodo-(L)-Tirosina via Reação de Suzuki-Miyaura Empregando Organotrifluoroboratos de Potássio
• Beneficiário: Stanley Nunes Siqueira Vasconcelos
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 12/00424-2 - Síntese de pequenas bibliotecas empregando organotrifluoroboratos de potássio em reações de Suzuki-Miyaura
• Beneficiário: Helio Alexandre Stefani
• Modalidade de apoio: Auxílio à Pesquisa - Temático