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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Immunological implications of bovine leukemia virus infection

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Autor(es):
Blagitz, M. G. [1] ; Souza, F. N. [1] ; Batista, C. F. [1] ; Azevedo, L. F. F. [1] ; Sanchez, E. M. R. [2] ; Diniz, S. A. [3] ; Silva, M. X. [3] ; Haddad, J. P. [3] ; Della Libera, A. M. M. P. [1]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Vet Clin Immunol Res Grp, Dept Clin Sci, Fac Vet Med & Anim Sci, Av Prof Dr Orlando Marques de Paiva 87, BR-05508270 Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Trop Med, Av Dr Eneas Carvalho de Aguiar 470, BR-05403000 Sao Paulo - Brazil
[3] Univ Fed Minas Gerais, Vet Sch, Dept Vet Prevent Med, Av Presidente Antonio Carlos 6627, BR-31270010 Belo Horizonte, MG - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: Research in Veterinary Science; v. 114, p. 109-116, OCT 2017.
Citações Web of Science: 6
Resumo

This study examined neutrophil and monocyte functions and the blood lymphocyte profile of naturally BLV-infected cows with or without persistent lymphocytosis (PL). The percentage of neutrophils and monocytes that phagocytosed Staphylococcus aureus was lower in BLV-infected dairy cows, particularly those with PL. The relative percentage of CD44(+) monocytes and neutrophils and CD11b expression by neutrophils was also lower in BLV-infected dairy cows with PL. A correlation between the percentage of CD11b(+) neutrophils and that produced reactive oxygen species (ROS) was found. Furthermore, the percentage of CD44(+) monocytes was positively correlated with the percentage of monocytes that phagocytosed S. aureus and the same phenomenon was observed for neutrophils. In BLV-infected dairy cows, particularly those with PL, inhibition of monocyte and neutrophil apoptosis was observed. Additionally, the percentage of neutrophils producing ROS was lower in BLV-infected cows with PL, in contrast to higher intensity of intracellular production of ROS by monocytes. The result from the lymphocyte immunophenotyping of BLV-infected cows with PL was an increase in B cells, mainly B CD5(+) CD11b(+), due to the apoptosis inhibition. In conclusion, this study provides novel insight into the implications of BLV infection for cattle, which can include the dysfunction of blood monocytes and neutrophils. (AU)

Processo FAPESP: 09/50672-0 - Avaliação funcional dos leucócitos sanguíneos e lácteos de vacas naturalmente infectados pelo vírus da leucose dos bovinos
Beneficiário:Alice Maria Melville Paiva Della Libera
Modalidade de apoio: Auxílio à Pesquisa - Regular