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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Immunological implications of bovine leukemia virus infection

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Author(s):
Blagitz, M. G. [1] ; Souza, F. N. [1] ; Batista, C. F. [1] ; Azevedo, L. F. F. [1] ; Sanchez, E. M. R. [2] ; Diniz, S. A. [3] ; Silva, M. X. [3] ; Haddad, J. P. [3] ; Della Libera, A. M. M. P. [1]
Total Authors: 9
Affiliation:
[1] Univ Sao Paulo, Vet Clin Immunol Res Grp, Dept Clin Sci, Fac Vet Med & Anim Sci, Av Prof Dr Orlando Marques de Paiva 87, BR-05508270 Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Trop Med, Av Dr Eneas Carvalho de Aguiar 470, BR-05403000 Sao Paulo - Brazil
[3] Univ Fed Minas Gerais, Vet Sch, Dept Vet Prevent Med, Av Presidente Antonio Carlos 6627, BR-31270010 Belo Horizonte, MG - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Research in Veterinary Science; v. 114, p. 109-116, OCT 2017.
Web of Science Citations: 6
Abstract

This study examined neutrophil and monocyte functions and the blood lymphocyte profile of naturally BLV-infected cows with or without persistent lymphocytosis (PL). The percentage of neutrophils and monocytes that phagocytosed Staphylococcus aureus was lower in BLV-infected dairy cows, particularly those with PL. The relative percentage of CD44(+) monocytes and neutrophils and CD11b expression by neutrophils was also lower in BLV-infected dairy cows with PL. A correlation between the percentage of CD11b(+) neutrophils and that produced reactive oxygen species (ROS) was found. Furthermore, the percentage of CD44(+) monocytes was positively correlated with the percentage of monocytes that phagocytosed S. aureus and the same phenomenon was observed for neutrophils. In BLV-infected dairy cows, particularly those with PL, inhibition of monocyte and neutrophil apoptosis was observed. Additionally, the percentage of neutrophils producing ROS was lower in BLV-infected cows with PL, in contrast to higher intensity of intracellular production of ROS by monocytes. The result from the lymphocyte immunophenotyping of BLV-infected cows with PL was an increase in B cells, mainly B CD5(+) CD11b(+), due to the apoptosis inhibition. In conclusion, this study provides novel insight into the implications of BLV infection for cattle, which can include the dysfunction of blood monocytes and neutrophils. (AU)

FAPESP's process: 09/50672-0 - Functional evaluation of blood and milk leukocytes of cows naturally infected by bovine leukosis virus
Grantee:Alice Maria Melville Paiva Della Libera
Support Opportunities: Regular Research Grants