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Germline Variation at CDKN2A and Associations with Nevus Phenotypes among Members of Melanoma Families

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Autor(es):
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Taylor, Nicholas J. [1] ; Mitra, Nandita [2] ; Goldstein, Alisa M. [3] ; Tucker, Margaret A. [3] ; Avil, Marie-Francoise [4, 5] ; Azizi, Esther [6] ; Bergman, Wilma [7] ; Bishop, D. Timothy [8] ; Bressac-de Paillerets, Brigitte [9] ; Bruno, William [10, 11] ; Calista, Donato [12] ; Cannon-Albright, Lisa A. [13, 14] ; Cuellar, Francisco [15, 16] ; Cust, Anne E. [17, 18] ; Demenais, Florence [19] ; Elder, David E. [20] ; Gerdes, Anne-Marie [21] ; Ghiorzo, Paola [8] ; Grazziotin, Thais C. [22] ; Hansson, Johan [23] ; Harland, Mark ; Hayward, Nicholas K. ; Hocevar, Marko [24] ; Hoiom, Veronica ; Ingvar, Christian [25, 26] ; Landi, Maria Teresa ; Landman, Gilles [27] ; Larre-Borges, Alejandra [28] ; Leachman, Sancy A. [29] ; Mann, Graham J. [30] ; Nagore, Eduardo [31] ; Olsson, Hakan ; Palmer, Jane M. [32] ; Peric, Barbara [24] ; Pjanova, Dace [33] ; Pritchard, Antonia ; Puig, Susana [15, 16] ; van der Stoep, Nienke [7] ; Wadt, Karin A. W. [21] ; Whitaker, Linda [8] ; Yang, Xiaohong R. [3] ; Bishop, Julia A. Newton [8] ; Gruis, Nelleke A. [7] ; Kanetsky, Peter A. [34] ; Grp, GenoMEL Study
Número total de Autores: 45
Afiliação do(s) autor(es):
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[1] Texas A&M Hlth Sci Ctr, Dept Epidemiol & Biostat, College Stn, TX - USA
[2] Univ Penn, Dept Biostat & Epidemiol, Philadelphia, PA - USA
[3] Natl Canc Inst, Div Canc Epidemiol & Genet, Human Genet Program, Bethesda, MD - USA
[4] Univ Paris 05, Paris - France
[5] Hop Cochin, AP HP, Paris - France
[6] Tel Aviv Univ, Sackler Fac Med, Sheba Med Ctr, Dept Dermatol, Tel Aviv - Israel
[7] Leiden Univ, Med Ctr, Dept Dermatol, Leiden - Netherlands
[8] St James Univ Hosp, Canc Res UK Clin Ctr Leeds, Leeds Inst Canc & Pathol, Sect Epidemiol & Biostat, Leeds, W Yorkshire - England
[9] Univ Paris Saclay, Gustave Roussy, Dept Biol & Pathol Med, INSERM, U1186, Villejuif - France
[10] Univ Genoa, Dept Internal Med & Med Specialties, Genoa - Italy
[11] IRCCS, AOU San Martino IST, Genoa - Italy
[12] Maurizio Bufalini Hosp, Dermatol Unit, Cesena - Italy
[13] Univ Utah, Dept Genet Epidemiol, Salt Lake City, UT - USA
[14] Univ Utah, Dept Biomed Informat, Salt Lake City, UT - USA
[15] Hosp Clin Barcelona, IDIBAPS, Dermatol Dept, Melanoma Unit, Barcelona - Spain
[16] CIBER Enfermedades Raras, Barcelona - Spain
[17] Univ Sydney, Sydney Sch Publ Hlth, Sydney, NSW - Australia
[18] Melanoma Inst Australia, Westmead, NSW - Australia
[19] Univ Paris Diderot, Univ Sorbonne Paris Cite, INSERM, Genet Variat & Human Dis Unit, UMR 946, Paris - France
[20] Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA - USA
[21] Univ Copenhagen Hosp, Dept Clin Genet, Copenhagen - Denmark
[22] Univ Fed Ciencias Sau Porto Alegre, Porto Alegre, RS - Brazil
[23] Karolinska Inst, Dept Oncol Pathol, Stockholm - Sweden
[24] Inst Oncol Ljubljana, Ljubljana - Slovenia
[25] Lund Univ, Dept Clin Sci, Lund - Sweden
[26] Lund Univ, Dept Surg, Lund - Sweden
[27] Univ Fed Sao Paulo, Escola Paulista Med, Dept Pathol, Sao Paulo - Brazil
[28] Univ Republica, Hosp Clin, Unidad Lesiones Pigmentadas Catedra Dermatol, Montevideo - Uruguay
[29] Oregon Hlth & Sci Univ, Dept Dermatol, Portland, OR 97201 - USA
[30] Univ Sydney, Westmead Millennium Inst, Westmead Inst Canc Res, Sydney, NSW - Australia
[31] Inst Valenciano Oncol, Dept Dermatol, Valencia - Spain
[32] QIMR Berghofer Med Res Inst, Herston, Qld - Australia
[33] Latvian Biomed Res & Study Ctr, Riga - Latvia
[34] H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, Tampa, FL - USA
Número total de Afiliações: 34
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF INVESTIGATIVE DERMATOLOGY; v. 137, n. 12, p. 2606-2612, DEC 2017.
Citações Web of Science: 5
Resumo

Germline mutations in CDKN2A are frequently identified among melanoma kindreds and are associated with increased atypical nevus counts. However, a clear relationship between pathogenic CDKN2A mutation carriage and other nevus phenotypes including counts of common acquired nevi has not yet been established. Using data from GenoMEL, we investigated the relationships between CDKN2A mutation carriage and 2-mm, 5-mm, and atypical nevus counts among blood-related members of melanoma families. Compared with individuals without a pathogenic mutation, those who carried one had an overall higher prevalence of atypical (odds ratio = 1.64; 95% confidence interval = 1.18-2.28) nevi but not 2-mm nevi (odds ratio = 1.06; 95% confidence interval = 0.92-1.21) or 5-mm nevi (odds ratio = 1.26; 95% confidence interval = 0.94-1.70). Stratification by case status showed more pronounced positive associations among non-case family members, who were nearly three times (odds ratio = 2.91; 95% confidence interval = 1.75-4.82) as likely to exhibit nevus counts at or above the median in all three nevus categories simultaneously when harboring a pathogenic mutation (vs. not harboring one). Our results support the hypothesis that unidentified nevogenic genes are co-inherited with CDKN2A and may influence carcinogenesis. (AU)

Processo FAPESP: 07/04313-2 - Fatores genéticos e de meio ambiente de risco para o desenvolvimento de melanoma na América Latina
Beneficiário:Gilles Landman
Linha de fomento: Auxílio à Pesquisa - Regular