Feature selection before EEG classification supports the diagnosis of Alzheimer's disease

Autor(es)

Trambaiolli, L. R. ^[1] ; Spolaor, N. ^[2] ; Lorena, A. C. ^[3] ; Anghinah, R. ^[4] ; Sato, J. R. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed ABC, Ctr Math Comp & Cognit, Santo Andre - Brazil

^[2] Univ Estadual Oeste Parana, Ctr Engn & Ciencias Exatas, Lab Bioinformat, Foz Do Iguacu - Brazil

^[3] Univ Fed Sao Paulo, Inst Ciencia & Tecnol, Sao Jose Dos Campos - Brazil

^[4] Univ Sao Paulo, Reference Ctr Cognit Disorders, Hosp Clin, Rua Arruda Alvim 206, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CLINICAL NEUROPHYSIOLOGY; v. 128, n. 10, p. 2058-2067, OCT 2017.
• Citações Web of Science: 10

Resumo

Objective: In many decision support systems, some input features can be marginal or irrelevant to the diagnosis, while others can be redundant among each other. Thus, feature selection (FS) algorithms are often considered to find relevant/non-redundant features.\& para;\& para;Objective: This study aimed to evaluate the relevance of FS approaches applied to Alzheimer's Disease (AD) EEG-based diagnosis and compare the selected features with previous clinical findings.\& para;\& para;Methods: Eight different FS algorithms were applied to EEG spectral measures from 22 AD patients and 12 healthy age-matched controls. The FS contribution was evaluated by considering the leave-one-subject-out accuracy of Support Vector Machine classifiers built in the datasets described by the selected features.\& para;\& para;Results: The Filtered Subset Evaluator technique achieved the best performance improvement both on a per-patient basis (91.18% of accuracy) and on a per-epoch basis (85.29 +/- 21.62%), after removing 88.76 +/- 1.12% of the original features. All algorithms found out that alpha and beta bands are relevant features, which is in agreement with previous findings from the literature.\& para;\& para;Conclusion: Biologically plausible EEG datasets could achieve improved accuracies with pre-processing FS steps.\& para;\& para;Significance: The results suggest that the FS and classification techniques are an attractive complementary tool in order to reveal potential biomarkers aiding the AD clinical diagnosis. (C) 2017 Published by Elsevier Ireland Ltd on behalf of International Federation of Clinical Neurophysiology. (AU)

• Processo FAPESP: 12/22608-8 - Uso de medidas de complexidade de dados no suporte ao aprendizado de máquina supervisionado
• Beneficiário: Ana Carolina Lorena
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 13/00506-1 - Séries temporais, ondaletas e análise de dados funcionais
• Beneficiário: Pedro Alberto Morettin
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 13/10952-9 - Avaliação do substrato neural do aprendizado de controle de interface cérebro-computador em indivíduos saudáveis
• Beneficiário: Lucas Remoaldo Trambaiolli
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 13/10498-6 - Aprendizado de máquina em neuroimagem: desenvolvimento de métodos e aplicações clínicas em transtornos psiquiátricos
• Beneficiário: João Ricardo Sato
• Modalidade de apoio: Auxílio à Pesquisa - Regular