Cheese supplemented with probiotics reduced the Candida levels in denture wearers-RCT

Autor(es)

Miyazima, T. Y. ^[1] ; Ishikawa, K. H. ^{[2, 1]} ; Mayer, M. P. A. ^[2] ; Saad, S. M. I. ^[3] ; Nakamae, A. E. M. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Dent, Dept Prosthodont, Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Sao Paulo, SP - Brazil

^[3] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Biochem & Pharmaceut Technol, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ORAL DISEASES; v. 23, n. 7, p. 919-925, OCT 2017.
• Citações Web of Science: 9

Resumo

Objectives: The access to probiotics should be facilitated in order to encourage their usage. We evaluated the effect of consumption of two experimental probiotic-containing cheeses on the oral colonization of Candida in denture wearers. Methods: Sixty denture wearers harboring oral Candida were randomly allocated in groups who received cheese supplemented with Lactobacillus acidophilus NCFM (T1) or Lactobacillus rhamnosus Lr-32 (T2), daily for 8 weeks, and a control group (C) who received a control cheese. Oral samples were obtained through a mouthwash, and Candida levels were determined (CFU/mL) at baseline and after the 8-week experimental period. Results: At baseline, the mean levels of Candida spp. (log CFU/mL) were similar among the groups. However, the mean levels of Candida were significantly reduced in groups T1 and T2 but not in C (Tukey, p<.05). The reduction in Candida oral levels occurred independently on the colonizing Candida species, participant age, and use of bi- or unimaxillary dentures. Conclusions: Daily consumption of cheese supplemented with probiotics, with either L. acidophilus NCFM or L. rhamnosus Lr-32, was able to reduce the colonization of oral Candida in complete denture wearers, suggesting its potential in reducing the risk of oral candidiasis in this highly susceptible population. (AU)

• Processo FAPESP: 10/01323-0 - Utilização de probióticos para o controle da prevalência de Candida oral em pacientes edentados totais: influência na produção de exoenzimas e susceptibilidade aos antifúngicos
• Beneficiário: Atlas Edson Moleros Nakamae
• Modalidade de apoio: Auxílio à Pesquisa - Regular