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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cheese supplemented with probiotics reduced the Candida levels in denture wearers-RCT

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Author(s):
Miyazima, T. Y. [1] ; Ishikawa, K. H. [2, 1] ; Mayer, M. P. A. [2] ; Saad, S. M. I. [3] ; Nakamae, A. E. M. [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Sch Dent, Dept Prosthodont, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Biochem & Pharmaceut Technol, Sao Paulo, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: ORAL DISEASES; v. 23, n. 7, p. 919-925, OCT 2017.
Web of Science Citations: 9
Abstract

Objectives: The access to probiotics should be facilitated in order to encourage their usage. We evaluated the effect of consumption of two experimental probiotic-containing cheeses on the oral colonization of Candida in denture wearers. Methods: Sixty denture wearers harboring oral Candida were randomly allocated in groups who received cheese supplemented with Lactobacillus acidophilus NCFM (T1) or Lactobacillus rhamnosus Lr-32 (T2), daily for 8 weeks, and a control group (C) who received a control cheese. Oral samples were obtained through a mouthwash, and Candida levels were determined (CFU/mL) at baseline and after the 8-week experimental period. Results: At baseline, the mean levels of Candida spp. (log CFU/mL) were similar among the groups. However, the mean levels of Candida were significantly reduced in groups T1 and T2 but not in C (Tukey, p<.05). The reduction in Candida oral levels occurred independently on the colonizing Candida species, participant age, and use of bi- or unimaxillary dentures. Conclusions: Daily consumption of cheese supplemented with probiotics, with either L. acidophilus NCFM or L. rhamnosus Lr-32, was able to reduce the colonization of oral Candida in complete denture wearers, suggesting its potential in reducing the risk of oral candidiasis in this highly susceptible population. (AU)

FAPESP's process: 10/01323-0 - Employment of probiotics for oral Candida prevalence control in complete dentures wearers: influence in exoenzyme production and antifungal susceptibility
Grantee:Atlas Edson Moleros Nakamae
Support Opportunities: Regular Research Grants