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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Chemical Composition and Antibacterial Activity of the Essential Oil of Vitex agnus-castus L. (Lamiaceae)

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Autor(es):
Goncalves, Regiane [1] ; Ayres, Vanessa F. S. [1] ; Carvalho, Carlos E. [1] ; Souza, Maria G. M. [2] ; Guimaraes, Anderson C. [1] ; Correa, Geone M. [1] ; Martins, Carlos H. G. [2] ; Takeara, Renata [1] ; Silva, Eliane O. [3] ; Crotti, Antonio E. M. [4]
Número total de Autores: 10
Afiliação do(s) autor(es):
[1] Univ Fed Amazonas, Inst Ciencias Exatas & Tecnol, Rua Nossa Senhora do Rosario 3863, BR-69103128 Itacotiara, AM - Brazil
[2] Univ Franca, Nucleo Pesquisas Ciencias Exatas & Tecnol, Av Dr Armando Salles de Oliveira 201, Parque Univ, BR-14404600 Franca, SP - Brazil
[3] Univ Fed Bahia, Inst Quim, Dept Quim Organ, Rua Barao de Jeremoabo S-N, BR-40170115 Salvador, BA - Brazil
[4] Univ Sao Paulo, Dept Quim, Fac Filosofia Ciencias & Letras Ribeirao Preto, Av Bandeirantes 3900, BR-14040901 Ribeirao Preto, SP - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: Anais da Academia Brasileira de Ciências; v. 89, n. 4, p. 2825-2832, OCT-DEC 2017.
Citações Web of Science: 1
Resumo

Abnormal multiplication of oral bacteria causes dental caries and dental plaque. These diseases continue to be major public health concerns worldwide, mainly in developing countries. In this study, the chemical composition and antimicrobial activity of the essential oil of Vitex agnus-castus leaves (VAC-EO) collected in the North of Brazil against a representative panel of cariogenic bacteria were investigated. The antimicrobial activity of VAC-EO was evaluated in terms of its minimum inhibitory concentration (MIC) values by using the broth microdilution method in 96-well microplates. The chemical constituents of VAC-EO were identified by gas chromatography (GC-FID) and gas chromatography. mass spectrometry (GC-MS). VAC. EO displayed some activity against all the investigated oral pathogens; MIC values ranged from 15.6 to 200 mu g/mL. VAC-EO had promising activity against Streptococcus mutans (MIC=15.6 mu g/mL), Lactobacillus casei (MIC=15.6 mu g/mL), and Streptococcus mitis (MIC=31.2 mu g/mL). The compounds 1,8-cineole (23.8%), (E)-beta-farnesene (14.6%), (E)-caryophyllene (12.5%), sabinene (11.4%), and alpha-terpinyl acetate (7.7%) were the major chemical constituents of VAC. EO. VAC-EO displays antimicrobial activity against cariogenic bacteria. The efficacy of VAC-EO against S. mutans is noteworthy and should be further investigated. (AU)

Processo FAPESP: 07/54241-8 - Prospecção de óleos essenciais de espécies brasileiras cultiváveis com atividade contra patógenos da cavidade bucal
Beneficiário:Antônio Eduardo Miller Crotti
Linha de fomento: Auxílio à Pesquisa - Programa BIOTA - Apoio a Jovens Pesquisadores