Protective effect of soybean oil- or fish oil-rich diets on allergic airway inflammation

Autor(es)

Navarro-Xavier, Roberta Araujo ^[1] ; de Barros, Karina Vieira ^[1] ; de Andrade, Iracema Senna ^[1] ; Palomino, Zaira ^[2] ; Casarini, Dulce Elena ^[2] ; Flor Silveira, Vera Lucia ^[3]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Fisiol, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Dept Med, Sao Paulo - Brazil

^[3] Univ Fed Sao Paulo, Dept Ciencias Biol, Campus Diadema, Rua Prof Artur Riedel 275, BR-09972270 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF INFLAMMATION RESEARCH; v. 9, 2016.
• Citações Web of Science: 4

Resumo

Background: The increased prevalence of asthma and allergic diseases in westernized societies has been associated with increased intake of diets rich in n-6 fatty acids (FAs) and poor in n-3 FAs. This study aimed to analyze the prophylactic effects of treatment with a soybean oil-rich diet (rich in n-6) or fish oil (rich in n-3) in an allergic airway inflammation model on lung inflammation score, leukocyte migration, T-helper cell (Th)-2 (interleukin {[}IL]-4, IL-5) and Th1 (interferon {[}IFN]-gamma, tumor necrosis factor-alpha) cytokines, lipoxin A4, nitric oxide, bradykinin, and corticosterone levels in bronchoalveolar lavage (BAL) or lungs. Methods: Male Wistar rats fed with soybean oil-or fish oil-rich diet or standard rat chow were sensitized twice with ovalbumin-alumen and challenged twice with ovalbumin aerosol. The BAL and lungs were examined 24 hours later. Results: Both diets, rich in n-6 or n-3 FAs, impaired the allergic lung inflammation and reduced leukocyte migration, eosinophil and neutrophil percentages, and IL-4/IL-5/bradykinin levels in BAL and/or lungs, as well as increased the nitric oxide levels in BAL. The soybean oil-rich diet additionally increased the levels of lipoxin A4 and corticosterone in the lungs. Conclusion: Data presented demonstrated that the n-6 FA-rich diet had protective effect upon allergic airway inflammation and was as anti-inflammatory as the n-3 FA-rich diet, although through different mechanisms, suggesting that both diets could be considered as complementary therapy or a prophylactic alternative for allergic airway inflammation. (AU)

• Processo FAPESP: 06/57075-9 - Efeito de dietas enriquecidas com acidos graxos poliinsaturados n-3 ou n-6 sobre a asma experimental, em ratos.
• Beneficiário: Vera Lucia Flor Silveira
• Modalidade de apoio: Auxílio à Pesquisa - Regular