Physical exercise as an epigenetic modulator of brain plasticity and cognition

Autor(es)

Fernandes, Jansen ^{[1, 2]} ; Arida, Ricardo Mario ^[2] ; Gomez-Pinilla, Fernando ^{[1, 3]}

Afiliação do(s) autor(es)

^[1] Univ Calif Los Angeles, Dept Integrat Biol & Physiol, Los Angeles, CA 90095 - USA

^[2] Univ Fed Sao Paulo UNIFESP, Escola Paulista Med, Dept Physiol, Sao Paulo, SP - Brazil

^[3] Univ Calif Los Angeles, Dept Neurosurg, UCLA Brain Injury Res Ctr, Los Angeles, CA 90095 - USA

• Tipo de documento: Artigo de Revisão
• Fonte: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS; v. 80, p. 443-456, SEP 2017.
• Citações Web of Science: 30

Resumo

A large amount of evidence has demonstrated the power of exercise to support cognitive function, the effects of which can last for considerable time. An emerging line of scientific evidence indicates that the effects of exercise are longer lasting than previously thought up to the point to affect future generations. The action of exercise on epigenetic regulation of gene expression seem central to building an ``epigenetic memory{''} to influence long-term brain function and behavior. In this review article, we discuss new developments in the epigenetic field connecting exercise with changes in cognitive function, including DNA methylation, histone modifications and microRNAs (miRNAs). The understanding of how exercise promotes long-term cognitive effects is crucial for directing the power of exercise to reduce the burden of neurological and psychiatric disorders. (AU)

• Processo FAPESP: 13/12692-4 - Influência do exercício aeróbico sobre a expressão e a distribuição de microRNAs na formação hipocampal de ratos adultos
• Beneficiário: Ricardo Mario Arida
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/09234-0 - Efeitos do exercício voluntário sobre a memória espacial e expressão de miRNAs associados ao BDNF após traumatismo crânio-encefálico
• Beneficiário: Jansen Fernandes
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
• Processo FAPESP: 13/13725-3 - Influência do Exercício Aeróbico Sobre a Expressão e a Distribuição de microRNAs na Formação Hipocampal de Ratos Adultos
• Beneficiário: Jansen Fernandes
• Modalidade de apoio: Bolsas no Brasil - Doutorado