High-level of resistance to beta-lactam and presence of beta-lactamases encoding genes in Ochrobactrum sp and Achromobacter sp isolated from soil

Autor(es)

Rueda Furlan, Joao Pedro ^[1] ; Stehling, Eliana Guedes ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Anal Clin Toxicol & Bromatol, Ribeirao Preto - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE; v. 11, p. 133-137, DEC 2017.
• Citações Web of Science: 4

Resumo

Objectives: Bacteria belonging to the genera Ochrobactrum and Achromobacter are bacteria considered opportunistic, causing infections mainly in immunocompromised patients. beta-lactamases are the main cause of resistance to beta-lactam antibiotics. This study aimed to investigate the antimicrobial resistance profile and the presence of beta-lactamases encoding genes in Ochrobactrum sp. and Achromobacter sp. isolated from Brazilian soils. Methods: Soil samples from the five regions of Brazil were collected for the isolation of bacteria, which were identified molecularly and then, the minimum inhibitory concentration and detection of beta-lactamases encoding genes were performed. Results: High-level of resistance to beta-lactam antibiotics and different beta-lactamases encoding genes were found (bla(CTX-M-Gp1), bla(SHV), bla(OXA-1-like) and bla(KPC)), including the first report of the presence of blaKPC in bacteria belonging to the genera Ochrobactrum and Achromobacter. Conclusion: The results showed that the bacteria from this study, belonging to genera Ochrobactrum and Achromobacter isolated from soil, harbor different b-lactamases encoding genes and can act as a reservoir of these genes. (C) 2017 International Society for Chemotherapy of Infection and Cancer. Published by Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 15/18990-2 - Investigação dos mecanismos de resistência às quinolonas em isolados bacterianos ambientais
• Beneficiário: Eliana Guedes Stehling
• Modalidade de apoio: Auxílio à Pesquisa - Regular