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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Development of sericin/alginate particles by ionic gelation technique for the controlled release of diclofenac sodium

Texto completo
Autor(es):
Martins Vidart, Jacyara Moreira [1] ; da Silva, Thiago Lopes [1] ; Pires Rosa, Paulo Cesar [2] ; Adeodato Vieira, Melissa Gurgel [1] ; Carlos da Silva, Meuris Gurgel [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Sch Chem Engn, 500 Albert Einstein Ave, BR-13083852 Campinas, SP - Brazil
[2] Univ Estadual Campinas, Sch Pharmaceut Sci, 250 Sergio Buarque de Holanda St, BR-13083859 Campinas, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Journal of Applied Polymer Science; v. 135, n. 12 MAR 20 2018.
Citações Web of Science: 9
Resumo

Sericin and alginate particles, prepared by ionic gelation technique, demonstrated to be a promising matrix to controlled release of diclofenac sodium. Ten particle compositions of sericin, alginate, and diclofenac were evaluated. The drug incorporation was confirmed by scanning electron microscopy, Fourier Transform Infrared Spectroscopy, and X-ray diffraction analysis. In vitro dissolution profile was performed to obtain the drug release profile in gastric and enteric medium. The drug release profile indicated that sericin delays the release and alginate contributes to the gastro-resistance of formulations. The blend with composition of 2.5% of sericin, 2.8% of alginate with 2.0% w/v of diclofenac demonstrated to be feasible for drug delivery due the entrapment efficiency of 81.06% and release delay of 360 min, the highest time of all investigated compositions. The mathematical modeling showed that the drug release mechanism is associated to the process of swelling, matrix erosion, and a combination of diffusion and chain relaxation mechanisms. (c) 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45919. (AU)

Processo FAPESP: 15/13505-9 - Incorporação e liberação de fármacos em micropartículas de sericina e alginato
Beneficiário:Melissa Gurgel Adeodato Vieira
Modalidade de apoio: Auxílio à Pesquisa - Regular