Development of sericin/alginate particles by ionic gelation technique for the controlled release of diclofenac sodium

Author(s)

Martins Vidart, Jacyara Moreira ^[1] ; da Silva, Thiago Lopes ^[1] ; Pires Rosa, Paulo Cesar ^[2] ; Adeodato Vieira, Melissa Gurgel ^[1] ; Carlos da Silva, Meuris Gurgel ^[1]

Affiliation

^[1] Univ Estadual Campinas, Sch Chem Engn, 500 Albert Einstein Ave, BR-13083852 Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Sch Pharmaceut Sci, 250 Sergio Buarque de Holanda St, BR-13083859 Campinas, SP - Brazil

• Document type: Journal article
• Source: Journal of Applied Polymer Science; v. 135, n. 12 MAR 20 2018.
• Web of Science Citations: 9

Abstract

Sericin and alginate particles, prepared by ionic gelation technique, demonstrated to be a promising matrix to controlled release of diclofenac sodium. Ten particle compositions of sericin, alginate, and diclofenac were evaluated. The drug incorporation was confirmed by scanning electron microscopy, Fourier Transform Infrared Spectroscopy, and X-ray diffraction analysis. In vitro dissolution profile was performed to obtain the drug release profile in gastric and enteric medium. The drug release profile indicated that sericin delays the release and alginate contributes to the gastro-resistance of formulations. The blend with composition of 2.5% of sericin, 2.8% of alginate with 2.0% w/v of diclofenac demonstrated to be feasible for drug delivery due the entrapment efficiency of 81.06% and release delay of 360 min, the highest time of all investigated compositions. The mathematical modeling showed that the drug release mechanism is associated to the process of swelling, matrix erosion, and a combination of diffusion and chain relaxation mechanisms. (c) 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45919. (AU)

• FAPESP's process: 15/13505-9 - INCORPORATION AND RELEASE OF DRUGS BY SERICIN-ALGINATE MICROPARTICLES
• Grantee: Melissa Gurgel Adeodato Vieira
• Support Opportunities: Regular Research Grants