Incorporation of the chemotherapy medication cisplatin into polyamide membrane

Autor(es)

de Souza, Erica A. ^[1] ; Rocha, Lucas A. ^[1] ; de Faria, Emerson H. ^[1] ; Ciuffi, Katia J. ^[1] ; Nassar, Eduardo J. ^[1] ; Silva, Jorge V. L. ^[2] ; Oliveira, Marcelo F. ^[2] ; Maia, Izaque A. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Franca, Ave Dr Armando Salles Oliveira, 201 Pq Univ, BR-14046000 Franca, SP - Brazil

^[2] Ctr Tecnol Informacao Renato Archer CTI, Rod Dom Pedro 1, Km 143, 6, BR-13069901 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Inorganic Biochemistry; v. 180, p. 171-178, MAR 2018.
• Citações Web of Science: 1

Resumo

The search for more efficient and less aggressive cancer treatment methods has intensified over the last decades and has involved many scientific areas. To provide skin cancer patients with better quality of life, this work aims to incorporate chemotherapy into polyamide membranes, functionalized by the sol-gel methodology, for controlled drug release at the target tissue. A 200-micrometer-thick flexible polyamide membrane prepared by Additive Manufacture was activated and functionalized with the alkoxide 3-chloropropyltriethoxysilane, which was followed by incorporation of the antitumor agent cisplatin. Membrane functionalization with the alkoxide was attested by infrared absorption spectroscopy, which evidenced a band at 1100 cm(-1), due to Si-O-Si vibration, and typical cisplatin bands at 3200 and 1600 cm(-1). The thermogravimetric curve revealed increased silicon oxide and platinum residues. Drug release was tested in simulated body fluid. Cytotoxicity was evaluated by the Cell Proliferation Kit, which gave IC50 of 23.95 mu gM. (AU)

• Processo FAPESP: 13/20443-4 - Incorporação de fármacos antitumorais em membrana de poliamida
• Beneficiário: Érica Adriene de Souza
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 15/20298-0 - Obtenção de matrizes luminescentes de LaNbO4:Ln (Ln = Dy, TM, er e Yb) pelo processo de pirólise de aerossol
• Beneficiário: Lucas Alonso Rocha
• Modalidade de apoio: Auxílio à Pesquisa - Regular