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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Short-term menthol treatment promotes persistent thermogenesis without induction of compensatory food consumption in Wistar rats: implications for obesity control

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Autor(es):
Lillo Vizin, Robson Cristiano [1] ; Motzko-Soares, Anna Carolina P. [1] ; Armentano, Giovana Marchini [2] ; Ishikawa, Debora T. [1] ; Cruz-Neto, Ariovaldo P. [3] ; Carrettiero, Daniel Carneiro [1, 2] ; Almeida, Maria Camila [1, 2]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Fed ABC, Grad Program Neurosci & Cognit, Sao Bernardo Do Campo, SP - Brazil
[2] Univ Fed ABC, Nat & Humanities Sci Ctr, Sao Bernardo Do Campo, SP - Brazil
[3] Sao Paulo State Univ, Biosci Inst, Dept Zool, Rio Claro, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: Journal of Applied Physiology; v. 124, n. 3, p. 672-683, MAR 2018.
Citações Web of Science: 5
Resumo

In this study, we aimed to evaluate the influence of daily repeated menthol treatments on body mass and thermoregulatory effectors in Wistar rats, considering that menthol is a transient receptor potential melastatin 8 channel agonist that mimics cold sensation and activates thermoregulatory cold-defense mechanisms in mammals, promoting hyperthermia and increasing energy expenditure, and has been suggested as an anti-obesity drug. Male Wistar rats were topically treated with 5% menthol for 3 or 9 consecutive days while body mass, food intake, abdominal temperature, metabolism, cutaneous vasoconstriction, and thermal preference were measured. Menthol promoted hyperthermia on all days of treatment, due to an increase in metabolism and cutaneous vasoconstriction, without affecting food intake, resulting in less mass gain in menthol-hyperthermic animals. As the treatment progressed, the menthol-induced increases in metabolism and hyperthermia were attenuated but not abolished. Moreover, cutaneous vasoconstriction was potentiated, and an increase in the warmth-seeking behavior was induced. Taken together, the results suggest that, although changes occur in thermoeffector recruitment during the course of short-term treatment, menthol is a promising drug to prevent body mass gain. NEW \& NOTEWORTHY Menthol produces a persistent increase in energy expenditure, with limited compensatory thermoregulatory adaptations and, most unexpectedly, without affecting food intake. Thus short-term treatment with menthol results in less mass gain in treated animals compared with controls. Our results suggest that menthol is a promising drug for the prevention of obesity. (AU)

Processo FAPESP: 13/25503-5 - Envolvimento dos canais TRPM8 na termorregulação de ratos Wistar
Beneficiário:Robson Cristiano Lillo Vizin
Modalidade de apoio: Bolsas no Brasil - Doutorado
Processo FAPESP: 15/02991-0 - Envolvimento dos canais TRPM8 na termorregulação de ratos Wistar
Beneficiário:Maria Camila Almeida
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 15/23426-9 - Beta amiloide na patologia de Alzheimer: morte ou sobrevivência? Envolvimento da via NF-kappaB e BAG2
Beneficiário:Daniel Carneiro Carrettiero
Modalidade de apoio: Auxílio à Pesquisa - Regular